Literature DB >> 211744

The influence of diazepam and thiouracil upon the carcinogenic effect of diethylnitrosamine in gerbils.

U Green, M Ketkar.   

Abstract

N-diethylnitrosamine (DEN) was simultaneously administered with diazepam (DZP) or thiouracil (TU) once weekly for life to gerbils (Meriones unguiculatus). Additional DZP or TU treatment increased significantly average survival time and inhibited the development of cholangiocarcinomas, although cholangiomas were still observed in these groups. Tumor type and incidence in the nasal cavities were not influenced by DZP or TU. However, in comparison to DEN alone tumor latencies were prolonged.

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Year:  1978        PMID： 211744     DOI： 10.1007/bf00284094

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN： 0084-5353


  10 in total

1.  Inhibition of drug metabolizing enzymes by diazepam in rat liver.

Authors:  M Vorne; J Idänpään-Heikkilä
Journal:  Experientia       Date:  1975-08-15

2.  Competitive action of 2-thiouracil and uracil in AAF-induced cancer of the liver.

Authors:  K E PASCHKIS; A CANTAROW; J STASNEY
Journal:  Science       Date:  1951-09-07       Impact factor: 47.728

3.  [Histogenesis and cytogenesis of cholangiofibromas and cholangiocarcinomas in nitrosomorpholine-intoxicated rats (author's transl)].

Authors:  P Bannasch; B Massner
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-12-09

4.  Inhibitory effects of 2-thiouracil and 2-thiouracil metabolites on enzymes involved in pyrimidine nucleotide biosynthesis.

Authors:  R H Lindsay; M W Yu
Journal:  Biochem Pharmacol       Date:  1974-08-15       Impact factor: 5.858

5.  Pharmacological implications of microsomal enzyme induction.

Authors:  A H Conney
Journal:  Pharmacol Rev       Date:  1967-09       Impact factor: 25.468

6.  The influence of hibernation upon the carcinogenic effect of N-diethylnitrosamine in European hamsters.

Authors:  U Mohr; J Althoff; R Spielhoff; H Bresch
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1973-12-28

Review 7.  Carcinogenic nitroso compounds.

Authors:  P N Magee; J M Barnes
Journal:  Adv Cancer Res       Date:  1967       Impact factor: 6.242

8.  In vitro metabolism and microsome-mediated mutagenicity of dialkylnitrosamines in rat, hamster, and mouse tissues.

Authors:  H Bartsch; C Malaveille; R Montesano
Journal:  Cancer Res       Date:  1975-03       Impact factor: 12.701

9.  Differential effect of phenobarbitone, pregnenolone-16-a-carbonitrile and adinoacetonitrile on dialkylnitrosamine metabolism and mutagenicity in vitro.

Authors:  H Bartsch; C Malaveille; R Montesano
Journal:  Chem Biol Interact       Date:  1975-05       Impact factor: 5.192

10.  Susceptibility of gerbils (Meriones unguiculatus) to weekly subcutaneous and single intravenous injections of N-diethylnitrosamine.

Authors:  H Haas; N Kmoch; U Mohr
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1975
  10 in total
  1 in total

1.  Effect of diazepam on microsomal diethylnitrosamine metabolism in gerbils.

Authors:  P Conradt; U Green
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553
  1 in total

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