Literature DB >> 21174372

Diphoterine for alkali chemical splashes to the skin at alumina refineries.

A Michael Donoghue1.   

Abstract

BACKGROUND: Diphoterine is a commercially available amphoteric, hypertonic, chelating solution used to decontaminate and irrigate chemical splashes. The aim of this study was to evaluate the implementation of Diphoterine at three alumina refineries. This is the largest case series reported to date.
METHODS: One hundred eighty cases of alkali splashes to the skin were evaluated clinically. Two groups were compared; those who had applied Diphoterine first and those who had applied water first.
RESULTS: There were no signs of chemical burn in 52.9% of the group who applied Diphoterine first compared with 21.4% of the group who applied water first. Only 7.9% of the group who applied Diphoterine first had blisters or more severe signs compared with 23.8% of the group who applied water first. The differences were statistically significant (P < 0.001). After implementation of Diphoterine the "first aid" injury rate for chemical burns fell 24.7% (95% CI 0.5–43.0%).
CONCLUSIONS: Applying Diphoterine first was associated with significantly better outcomes following alkali skin splashes than applying water first.
© 2010 The International Society of Dermatology.

Entities:  

Mesh:

Substances:

Year:  2010        PMID: 21174372     DOI: 10.1111/j.1365-4632.2009.04397.x

Source DB:  PubMed          Journal:  Int J Dermatol        ISSN: 0011-9059            Impact factor:   2.736


  3 in total

1.  The clinical efficacy of Diphoterine® in the management of cutaneous chemical burns: a 2-year evaluation study.

Authors:  S D L Zack-Williams; Z Ahmad; N S Moiemen
Journal:  Ann Burns Fire Disasters       Date:  2015-03-31

2. 

Authors:  J L Fortin; L Bodson; M Fontaine; A Depil-Duval; P Paulin; M P Bitar; F Ravat; J M Macher; A Hall
Journal:  Ann Burns Fire Disasters       Date:  2017-12-31

Review 3.  Bauxite mining and alumina refining: process description and occupational health risks.

Authors:  A Michael Donoghue; Neale Frisch; David Olney
Journal:  J Occup Environ Med       Date:  2014-05       Impact factor: 2.162

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.