Literature DB >> 21174185

Cardiotoxic overdose treated with intravenous fat emulsion and high-dose insulin in the setting of hypertrophic cardiomyopathy.

Samuel J Stellpflug1, Sandy J Fritzlar, Jon B Cole, Kristin M Engebretsen, Joel S Holger.   

Abstract

High-dose insulin (HDI) and intravenous fat emulsion (IFE) are used in overdoses, although rarely combined. To our knowledge, IFE therapy has not been reported in overdoses of diltiazem, metoprolol and amiodarone. We report a severe overdose of these drugs treated with HDI and IFE in a patient with hypertrophic cardiomyopathy (HCM). We also discuss the potential clinical implications of the inotropic effects of HDI in the setting of HCM and the use and efficacy of IFE in this overdose.

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Year:  2011        PMID： 21174185      PMCID： PMC3724444          DOI： 10.1007/s13181-010-0133-3

Source DB:  PubMed          Journal:  J Med Toxicol        ISSN： 1556-9039


  11 in total

Review 1.  Hypertrophic cardiomyopathy: a systematic review.

Authors:  Barry J Maron
Journal:  JAMA       Date:  2002-03-13       Impact factor: 56.272

2.  Fatal unintentional overdose of diltiazem with antemortem and postmortem values.

Authors:  F Lee Cantrell; Saralyn R Williams
Journal:  Clin Toxicol (Phila)       Date:  2005       Impact factor: 4.467

3.  Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high-dose insulin.

Authors:  Samuel J Stellpflug; Carson R Harris; Kristin M Engebretsen; Jon B Cole; Joel S Holger
Journal:  Clin Toxicol (Phila)       Date:  2010-03       Impact factor: 4.467

Review 4.  Treatment of poisoning caused by beta-adrenergic and calcium-channel blockers.

Authors:  Greene Shepherd
Journal:  Am J Health Syst Pharm       Date:  2006-10-01       Impact factor: 2.637

5.  Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium.

Authors:  Dirk von Lewinski; Sebastian Bruns; Stefanie Walther; Harald Kögler; Burkert Pieske
Journal:  Circulation       Date:  2005-05-09       Impact factor: 29.690

6.  Amiodarone overdose and its management.

Authors:  C J Goddard; P J Whorwell
Journal:  Br J Clin Pract       Date:  1989-05

7.  Effects of calcium channel blocker overdose-induced toxicity in the conscious dog.

Authors:  J M Schoffstall; W H Spivey; L M Gambone; R P Shaw; S P Sit
Journal:  Ann Emerg Med       Date:  1991-10       Impact factor: 5.721

8.  Fatality resulting from metoprolol overdose.

Authors:  T P Rohrig; D A Rundle; W N Leifer
Journal:  J Anal Toxicol       Date:  1987 Sep-Oct       Impact factor: 3.367

Review 9.  Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies.

Authors:  Chloé Jamaty; Benoit Bailey; Alexandre Larocque; Eric Notebaert; Karine Sanogo; Jean-Marc Chauny
Journal:  Clin Toxicol (Phila)       Date:  2010-01       Impact factor: 4.467

Review 10.  Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review.

Authors:  Grant Cave; Martyn Harvey
Journal:  Acad Emerg Med       Date:  2009-09       Impact factor: 3.451
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  7 in total

1.  Use of a Porcine Model to Evaluate the Risks and Benefits of Vasopressors in Propranolol Poisoning.

Authors:  Jon B Cole; Justin N Corcoran; Kristin M Engebretsen; Samuel J Stellpflug
Journal:  J Med Toxicol       Date:  2020-01-24

2.  Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock.

Authors:  Christine M Murphy; Cliff Williams; Michael E Quinn; Brian Nicholson; Thomas Shoe; Michael C Beuhler; William P Kerns
Journal:  J Med Toxicol       Date:  2016-08-08

3.  Asystole immediately following intravenous fat emulsion for overdose.

Authors:  Jon B Cole; Samuel J Stellpflug; Kristin M Engebretsen
Journal:  J Med Toxicol       Date:  2014-09

4.  Intravenous Fat Emulsion Does Not Significantly Alter Clotting Markers in Dabigatran-Treated Blood.

Authors:  Samuel J Stellpflug; Michael E Bond; Keith D Henry; Kristin M Engebretsen; Nicole D Zantek
Journal:  Indian J Hematol Blood Transfus       Date:  2020-06-22       Impact factor: 0.900

5.  High dose insulin therapy, an evidence based approach to beta blocker/calcium channel blocker toxicity.

Authors:  Christina Woodward; Ali Pourmand; Maryann Mazer-Amirshahi
Journal:  Daru       Date:  2014-04-08       Impact factor: 3.117

6.  Severe diltiazem poisoning treated with hyperinsulinaemia-euglycaemia and lipid emulsion.

Authors:  Nadine Monteiro; Joana Silvestre; João Gonçalves-Pereira; Camila Tapadinhas; Vitor Mendes; Pedro Póvoa
Journal:  Case Rep Crit Care       Date:  2013-05-20

Review 7.  Treatment for calcium channel blocker poisoning: a systematic review.

Authors:  M St-Onge; P-A Dubé; S Gosselin; C Guimont; J Godwin; P M Archambault; J-M Chauny; A J Frenette; M Darveau; N Le Sage; J Poitras; J Provencher; D N Juurlink; R Blais
Journal:  Clin Toxicol (Phila)       Date:  2014-10-06       Impact factor: 4.467
  7 in total

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