Literature DB >> 2117396

HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. A case report, with analysis of isolated follicular dendritic cells.

H K Parmentier1, D van Wichen, D M Sie-Go, J Goudsmit, J C Borleffs, H J Schuurman.   

Abstract

Follicular dendritic cells (FDC) from axillary lymphoid tissue of a patient with acquired immune deficiency syndrome (AIDS) were analyzed for the presence of gag and env proteins and env mRNA of human immunodeficiency virus type-1 (HIV-1), both in a purified FDC suspension and on frozen sections. Isolated cells with morphologic and immunocytochemical features of FDC expressed HIV-1 core (gag) proteins p15, p17, p24, and envelope (env) protein gp41; in addition HIV-1 env mRNA was detected in some of these cells. This corresponded with intense expression of HIV-1 proteins by FDC in germinal centers in situ, and the presence of HIV-1 mRNA-positive cells in germinal follicles. These findings led us to conclude that FDC are infected and able to produce HIV-1. Such infection may contribute significantly to the destruction of the FDC network during the lymphadenopathy phase after HIV-1 infection.

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Year:  1990        PMID： 2117396      PMCID： PMC1877608     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  16 in total

1.  Detection of calcitonin-encoding mRNA by radioactive and non-radioactive in situ hybridization: improved colorimetric detection and cellular localization of mRNA in thyroid sections.

Authors:  M Denijn; R A De Weger; M J Berends; P I Compier-Spies; H Jansz; J A Van Unnik; C J Lips
Journal:  J Histochem Cytochem       Date:  1990-03       Impact factor: 2.479

2.  Isolation of follicular dendritic cells from human tonsils and adenoids. III. Analysis of their Fc receptors.

Authors:  E Heinen; D Radoux; C Kinet-Denoel; M Moeremans; J De Mey; L J Simar
Journal:  Immunology       Date:  1985-04       Impact factor: 7.397

3.  Isolation of follicular dendritic cells from human tonsils and adenoids. I. Procedure and morphological characterization.

Authors:  C Lilet-Leclercq; D Radoux; E Heinen; C Kinet-Denoël; J O Defraigne; M P Houben-Defresne; L J Simar
Journal:  J Immunol Methods       Date:  1984-02-10       Impact factor: 2.303

4.  Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization.

Authors:  M E Harper; L M Marselle; R C Gallo; F Wong-Staal
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

5.  HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS.

Authors:  K Tenner-Racz; P Racz; M Bofill; A Schulz-Meyer; M Dietrich; P Kern; J Weber; A J Pinching; F Veronese-Dimarzo; M Popovic
Journal:  Am J Pathol       Date:  1986-04       Impact factor: 4.307

6.  Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy.

Authors:  J A Armstrong; R Horne
Journal:  Lancet       Date:  1984-08-18       Impact factor: 79.321

7.  LAV-like viral particles in lymph node germinal centers in patients with the persistent lymphadenopathy syndrome and the acquired immunodeficiency syndrome-related complex: an ultrastructural study of 30 cases.

Authors:  A Le Tourneau; J Audouin; J Diebold; C Marche; V Tricottet; M Reynes
Journal:  Hum Pathol       Date:  1986-10       Impact factor: 3.466

8.  Human dendritic cells and macrophages. In situ immunophenotypic definition of subsets that exhibit specific morphologic and microenvironmental characteristics.

Authors:  G S Wood; R R Turner; R A Shiurba; L Eng; R A Warnke
Journal:  Am J Pathol       Date:  1985-04       Impact factor: 4.307

9.  The immunohistology of the persistent generalized lymphadenopathy syndrome (PGL).

Authors:  C F Garcia; J D Lifson; E G Engleman; D M Schmidt; R A Warnke; G S Wood
Journal:  Am J Clin Pathol       Date:  1986-12       Impact factor: 2.493

10.  An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS.

Authors:  G Janossy; A J Pinching; M Bofill; J Weber; J E McLaughlin; M Ornstein; K Ivory; J R Harris; M Favrot; D C Macdonald-Burns
Journal:  Clin Exp Immunol       Date:  1985-02       Impact factor: 4.330
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  15 in total

Review 1.  Follicular dendritic cells: dynamic antigen libraries.

Authors:  Balthasar A Heesters; Riley C Myers; Michael C Carroll
Journal:  Nat Rev Immunol       Date:  2014-06-20       Impact factor: 53.106

2.  Treatment-induced decline of human immunodeficiency virus-1 p24 and HIV-1 RNA in lymphoid tissue of patients with early human immunodeficiency virus-1 infection.

Authors:  H Kuster; M Opravil; P Ott; E Schlaepfer; M Fischer; H F Günthard; R Lüthy; R Weber; R W Cone
Journal:  Am J Pathol       Date:  2000-06       Impact factor: 4.307

3.  Lymphoid organs function as major reservoirs for human immunodeficiency virus.

Authors:  G Pantaleo; C Graziosi; L Butini; P A Pizzo; S M Schnittman; D P Kotler; A S Fauci
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

4.  Localization of the viral antigen of feline immunodeficiency virus in the lymph nodes of cats at the early stage of infection.

Authors:  T Toyosaki; T Miyazawa; T Furuya; K Tomonaga; Y S Shin; M Okita; Y Kawaguchi; C Kai; S Mori; T Mikami
Journal:  Arch Virol       Date:  1993       Impact factor: 2.574

5.  Early stages of simian immunodeficiency virus infection in lymph nodes. Evidence for high viral load and successive populations of target cells.

Authors:  L Chakrabarti; P Isola; M C Cumont; M A Claessens-Maire; M Hurtrel; L Montagnier; B Hurtrel
Journal:  Am J Pathol       Date:  1994-06       Impact factor: 4.307

6.  Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells.

Authors:  H Spiegel; H Herbst; G Niedobitek; H D Foss; H Stein
Journal:  Am J Pathol       Date:  1992-01       Impact factor: 4.307

7.  Epitopes of human immunodeficiency virus regulatory proteins tat, nef, and rev are expressed in normal human tissue.

Authors:  H K Parmentier; D F van Wichen; F H Meyling; J Goudsmit; H J Schuurman
Journal:  Am J Pathol       Date:  1992-11       Impact factor: 4.307

8.  In situ hybridization AT-tailing with catalyzed signal amplification for sensitive and specific in situ detection of human immunodeficiency virus-1 mRNA in formalin-fixed and paraffin-embedded tissues.

Authors:  Noriko Nakajima; Petronela Ionescu; Yuko Sato; Michie Hashimoto; Toshihiro Kuroita; Hidehiro Takahashi; Hiroshi Yoshikura; Tetsutaro Sata
Journal:  Am J Pathol       Date:  2003-02       Impact factor: 4.307

9.  Analysis of human immunodeficiency virus-infected tissues by amplification and in situ hybridization reveals latent and permissive infections at single-cell resolution.

Authors:  J Embretson; M Zupancic; J Beneke; M Till; S Wolinsky; J L Ribas; A Burke; A T Haase
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205

10.  Variable course of primary simian immunodeficiency virus infection in lymph nodes: relation to disease progression.

Authors:  L Chakrabarti; M C Cumont; L Montagnier; B Hurtrel
Journal:  J Virol       Date:  1994-10       Impact factor: 5.103
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