Literature DB >> 21173953

A new dehydrogenase from Clostridium acetobutylicum for asymmetric synthesis: dynamic reductive kinetic resolution entry into the Taxotère side chain.

Gregory A Applegate1, Ross W Cheloha, David L Nelson, David B Berkowitz.   

Abstract

An NADP-dependent alcohol dehydrogenase from Clostridium acetobutylicum (CaADH) has been expressed and characterized. CaADH enantioselectively reduces aromatic α-, β- and γ-keto esters to the corresponding D-hydroxy esters and provides a building block for the Taxotère side chain (95% yield, 95% de, 99% ee) by dynamic reductive kinetic resolution (DYRKR).

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Year:  2010        PMID： 21173953      PMCID： PMC4882475          DOI： 10.1039/c0cc04585c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  42 in total

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4.  Changes in protein synthesis and identification of proteins specifically induced during solventogenesis in Clostridium acetobutylicum.

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  6 in total

1.  Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis.

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6.  Efficient biosynthesis of ethyl (R)-4-chloro-3-hydroxybutyrate using a stereoselective carbonyl reductase from Burkholderia gladioli.

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Journal:  BMC Biotechnol       Date:  2016-10-18       Impact factor: 2.563
  6 in total

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