| Literature DB >> 21173952 |
Alexander G O'Brien1, François Lévesque, Peter H Seeberger.
Abstract
An efficient, safe and scalable procedure for the continuous flow thermolysis of azidoacrylates to yield indoles has been developed and was applied to the synthesis of related heterocycles. The scalability of the process was demonstrated in the continuous flow synthesis of a precursor to the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid.Entities:
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Year: 2010 PMID： 21173952 DOI： 10.1039/c0cc04481d
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222