Literature DB >> 21173174

In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC.

A Briales1, J M Rodríguez-Martínez, C Velasco, P Díaz de Alba, J Domínguez-Herrera, J Pachón, A Pascual.   

Abstract

This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 μg/ml. qnr genes present in E. coli that harbored a Ser83Leu substitution in GyrA increased mutant prevention concentration (MPC) values to 8 to 32 μg/ml. qnr gene expression in E. coli may play an important role in selecting for one-step FQ-resistant mutants.

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Year:  2010        PMID： 21173174      PMCID： PMC3067081          DOI： 10.1128/AAC.00927-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Mutant prevention concentrations of ciprofloxacin for urinary tract infection isolates of Escherichia coli.

Authors:  Linda L Marcusson; Sara K Olofsson; Patricia Komp Lindgren; Otto Cars; Diarmaid Hughes
Journal:  J Antimicrob Chemother       Date:  2005-04-28       Impact factor: 5.790

2.  In vivo selection of fluoroquinolone-resistant Escherichia coli isolates expressing plasmid-mediated quinolone resistance and expanded-spectrum beta-lactamase.

Authors:  Laurent Poirel; Johann D D Pitout; Lucy Calvo; Jose-Manuel Rodriguez-Martinez; Deirdre Church; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

Review 3.  Mutant selection window hypothesis updated.

Authors:  Karl Drlica; Xilin Zhao
Journal:  Clin Infect Dis       Date:  2007-01-24       Impact factor: 9.079

4.  Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1.

Authors:  J M Rodríguez-Martínez; C Velasco; I García; M E Cano; L Martínez-Martínez; A Pascual
Journal:  Antimicrob Agents Chemother       Date:  2007-04-02       Impact factor: 5.191

Review 5.  A unified anti-mutant dosing strategy.

Authors:  Xilin Zhao; Karl Drlica
Journal:  J Antimicrob Chemother       Date:  2008-06-10       Impact factor: 5.790

6.  Interplay in the selection of fluoroquinolone resistance and bacterial fitness.

Authors:  Linda L Marcusson; Niels Frimodt-Møller; Diarmaid Hughes
Journal:  PLoS Pathog       Date:  2009-08-07       Impact factor: 6.823

7.  Impact of low-level resistance to fluoroquinolones due to qnrA1 and qnrS1 genes or a gyrA mutation on ciprofloxacin bactericidal activity in a murine model of Escherichia coli urinary tract infection.

Authors:  Nicolas Allou; Emmanuelle Cambau; Laurent Massias; Françoise Chau; Bruno Fantin
Journal:  Antimicrob Agents Chemother       Date:  2009-07-27       Impact factor: 5.191

Review 8.  Plasmid-mediated quinolone resistance.

Authors:  Luis Martínez-Martínez; María Eliecer Cano; José Manuel Rodríguez-Martínez; Jorge Calvo; Alvaro Pascual
Journal:  Expert Rev Anti Infect Ther       Date:  2008-10       Impact factor: 5.091

9.  Contributions of the combined effects of topoisomerase mutations toward fluoroquinolone resistance in Escherichia coli.

Authors:  Sonia K Morgan-Linnell; Lynn Zechiedrich
Journal:  Antimicrob Agents Chemother       Date:  2007-08-06       Impact factor: 5.191

10.  Activity of ciprofloxacin and levofloxacin in experimental pneumonia caused by Klebsiella pneumoniae deficient in porins, expressing active efflux and producing QnrA1.

Authors:  J M Rodríguez-Martínez; C Pichardo; I García; M E Pachón-Ibañez; F Docobo-Pérez; A Pascual; J Pachón; L Martínez-Martínez
Journal:  Clin Microbiol Infect       Date:  2008-07       Impact factor: 8.067
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  22 in total

Review 1.  Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones.

Authors:  Louis B Rice
Journal:  Mayo Clin Proc       Date:  2012-02       Impact factor: 7.616

Review 2.  Plasmid-mediated quinolone resistance.

Authors:  George A Jacoby; Jacob Strahilevitz; David C Hooper
Journal:  Microbiol Spectr       Date:  2014-10

3.  CTX-M-33, a CTX-M-15 derivative conferring reduced susceptibility to carbapenems.

Authors:  Laurent Poirel; José-Manuel Ortiz de la Rosa; Anaïs Richard; Marta Aires-de-Sousa; Patrice Nordmann
Journal:  Antimicrob Agents Chemother       Date:  2019-09-16       Impact factor: 5.191

4.  Mutations That Enhance the Ciprofloxacin Resistance of Escherichia coli with qnrA1.

Authors:  Laura Vinué; Marian A Corcoran; David C Hooper; George A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2015-12-28       Impact factor: 5.191

Review 5.  Treatment of Infections Caused by Extended-Spectrum-Beta-Lactamase-, AmpC-, and Carbapenemase-Producing Enterobacteriaceae.

Authors:  Jesús Rodríguez-Baño; Belén Gutiérrez-Gutiérrez; Isabel Machuca; Alvaro Pascual
Journal:  Clin Microbiol Rev       Date:  2018-02-14       Impact factor: 26.132

Review 6.  Mechanisms of drug resistance: quinolone resistance.

Authors:  David C Hooper; George A Jacoby
Journal:  Ann N Y Acad Sci       Date:  2015-07-17       Impact factor: 5.691

7.  Coastal seawater bacteria harbor a large reservoir of plasmid-mediated quinolone resistance determinants in Jiaozhou Bay, China.

Authors:  Jing-yi Zhao; Hongyue Dang
Journal:  Microb Ecol       Date:  2012-01-18       Impact factor: 4.552

8.  Characterization of the complete sequences and stability of plasmids carrying the genes aac(6')-Ib-cr or qnrS in Shigella flexneri in the Hangzhou area of China.

Authors:  Xiao-Ying Pu; Yaming Gu; Jun Li; Shu-Juan Song; Zhe Lu
Journal:  World J Microbiol Biotechnol       Date:  2018-05-18       Impact factor: 3.312

9.  The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic.

Authors:  Lipeng Feng; Julia E A Mundy; Clare E M Stevenson; Lesley A Mitchenall; David M Lawson; Kaixia Mi; Anthony Maxwell
Journal:  Proc Natl Acad Sci U S A       Date:  2021-03-16       Impact factor: 11.205

10.  Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance.

Authors:  Jun Tao; Jiao Han; Hanyu Wu; Xinling Hu; Jiaoyu Deng; Joy Fleming; Anthony Maxwell; Lijun Bi; Kaixia Mi
Journal:  Nucleic Acids Res       Date:  2012-12-28       Impact factor: 16.971
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