| Literature DB >> 21172256 |
W G N Mares1, D R Wong, L P L Gilissen, A A M Masclee, P M Hooymans, L G J B Engels.
Abstract
The immunosuppressive thiopurines, azathioprine (AZA) and 6-mercaptopurine (6-MP), have proven efficacy in steroid-dependant or refractory inflammatory bowel disease (IBD). In case of TPMT deficiency serious myelosuppression may occur. 6-thioguanine (6-TG), has been suggested in case of AZA and 6-MP resistant or intolerant patients. Our case demonstrates that very low dose 6-TG under close clinical surveillance and frequent therapeutic drug monitoring, may be a rescue drug for IBD-patients with low or without functional TPMT activity.Entities:
Year: 2009 PMID： 21172256 DOI： 10.1016/j.crohns.2009.02.002
Source DB: PubMed Journal: J Crohns Colitis ISSN： 1873-9946 Impact factor: 9.071