Literature DB >> 2117183

Activation of natural killer cells and cytokine production in humans by bacterial extracts (OM-85 BV).

J Wybran1, M Libin, L Schandene.   

Abstract

The influence of Broncho-Vaxom (BV) on different immune parameters was investigated in vitro on human peripheral blood mononuclear cells (PBMC). It was found that BV enhances the natural killer (NK) activity of PBMC and increases their spontaneous and phytohemagglutin (PHA)-induced production of tumor-necrosis factor--alpha and interleukin-2 as well as the PHA-stimulated production of interferon-gamma. These immunostimulating actions of BV on NK activity and cytokine production can contribute to the understanding of the enhancement of the body's defense mechanisms against respiratory tract infections.

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Year:  1990        PMID: 2117183     DOI: 10.1007/bf02718199

Source DB:  PubMed          Journal:  Lung        ISSN: 0341-2040            Impact factor:   2.584


  1 in total

1.  Activation of natural killer cells and cytokine production in man by bacterial extracts.

Authors:  J Wybran; M Libin; L Schandene
Journal:  Immunopharmacol Immunotoxicol       Date:  1989       Impact factor: 2.730

  1 in total
  4 in total

1.  Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element.

Authors:  R Keul; M Roth; E Papakonstantinou; M Nauck; A P Perruchoud; L H Block
Journal:  Thorax       Date:  1996-02       Impact factor: 9.139

2.  Distinct effects of Broncho-Vaxom (OM-85 BV) on gp130 binding cytokines.

Authors:  M Roth; L H Block
Journal:  Thorax       Date:  2000-08       Impact factor: 9.139

3.  Prospective, randomized comparison of OM-85 BV and a prophylactic antibiotic in children with recurrent infections and immunoglobulin A and/or G subclass deficiency.

Authors:  Ferah Genel; Necil Kutukculer
Journal:  Curr Ther Res Clin Exp       Date:  2003-09

4.  Evidence that a primary anti-viral stimulation of the immune response by OM-85 reduces susceptibility to a secondary respiratory bacterial infection in mice.

Authors:  Giovanni A Rossi; Wolfgang Bessler; Stefania Ballarini; Christian Pasquali
Journal:  Ital J Pediatr       Date:  2018-09-26       Impact factor: 2.638

  4 in total

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