Literature DB >> 21170872

Phosphate transport in the kidney.

Heini Murer1, Jürg Biber.   

Abstract

In kidneys of mammals, filtered phosphate ions (Pi) are reabsorbed along the proximal tubules. Transcellular transport of phosphate is initiated by several apically localized sodium-dependent Pi cotransporters (Na/Pi-cotransporters) that belong to the SLC 20 (SLC20A2) and 34 (SLC34A1, SLC34A3) families. Apical abundance of these Na/Pi-cotransporters is adjusted by numerous hormones/phosphatonins and metabolic factors in order to adjust the extent of renal Pi reabsorption according to body needs. Acute hormonal regulation of Pi reabsorption occurs mainly by a change of the abundance of SLC34A1 (NaPi-IIa) via modulation of the interaction of NaPi-IIa with the PDZ-protein NHERF1.

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Year:  2010        PMID： 21170872

Source DB:  PubMed          Journal:  J Nephrol        ISSN： 1121-8428            Impact factor:   3.902


  14 in total

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3.  Ezrin-anchored protein kinase A coordinates phosphorylation-dependent disassembly of a NHERF1 ternary complex to regulate hormone-sensitive phosphate transport.

Authors:  Bin Wang; Chris K Means; Yanmei Yang; Tatyana Mamonova; Alessandro Bisello; Daniel L Altschuler; John D Scott; Peter A Friedman
Journal:  J Biol Chem       Date:  2012-05-24       Impact factor: 5.157

4.  Pharmacological Npt2a Inhibition Causes Phosphaturia and Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function.

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Review 7.  FGF23 associated bone diseases.

Authors:  Eryuan Liao
Journal:  Front Med       Date:  2013-03-09       Impact factor: 4.592

8.  The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levels.

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9.  The kidney sodium-phosphate co-transporter alters bone quality in an age and gender specific manner.

Authors:  Adele L Boskey; Lyudmilla Lukashova; Lyudmila Spevak; Yan Ma; Saeed R Khan
Journal:  Bone       Date:  2013-01-17       Impact factor: 4.398

10.  A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.

Authors:  J Christopher Hennings; Nicolas Picard; Antje K Huebner; Tobias Stauber; Hannes Maier; Dennis Brown; Thomas J Jentsch; Rosa Vargas-Poussou; Dominique Eladari; Christian A Hübner
Journal:  EMBO Mol Med       Date:  2012-08-30       Impact factor: 12.137
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