BACKGROUND: Post-transplant anemia is multifactorial and highly prevalent. Some studies have associated anemia with mortality and graft failure. The purpose of this study was to assess whether the presence of anemia at 1 year is an independent risk factor of mortality and graft survival. METHODS: All patients transplanted at a single center who survived at least 1 year after transplantation and showed no graft loss (n = 214) were included. Demographic and clinical data were collected at baseline and at 1 year. Patients were divided into two groups (anemic and nonanemic) based on the presence of anemia (hemoglobin < 130 g/l in men and 120 g/l in women). RESULTS: Baseline characteristics such as age, gender, type of donor, CKD etiology, rejection, and mismatches were similar in both groups. Creatinine clearance was similar in both anemic and nonanemic groups (69.32 ± 29.8 × 75.69 ± 30.5 ml/mim; P = 0.17). A Kaplan-Meier plot showed significantly poorer death-censored graft survival in the anemic group, P = 0.003. Multivariate analysis revealed that anemic patients had a hazard ratio for the graft loss of 3.85 (95% CI: 1.49-9.96; P = 0.005). CONCLUSIONS: In this study, anemia at 1 year was independently associated with death-censored graft survival and anemic patients were 3.8-fold more likely to lose the graft.
BACKGROUND: Post-transplant anemia is multifactorial and highly prevalent. Some studies have associated anemia with mortality and graft failure. The purpose of this study was to assess whether the presence of anemia at 1 year is an independent risk factor of mortality and graft survival. METHODS: All patients transplanted at a single center who survived at least 1 year after transplantation and showed no graft loss (n = 214) were included. Demographic and clinical data were collected at baseline and at 1 year. Patients were divided into two groups (anemic and nonanemic) based on the presence of anemia (hemoglobin < 130 g/l in men and 120 g/l in women). RESULTS: Baseline characteristics such as age, gender, type of donor, CKD etiology, rejection, and mismatches were similar in both groups. Creatinine clearance was similar in both anemic and nonanemic groups (69.32 ± 29.8 × 75.69 ± 30.5 ml/mim; P = 0.17). A Kaplan-Meier plot showed significantly poorer death-censored graft survival in the anemic group, P = 0.003. Multivariate analysis revealed that anemicpatients had a hazard ratio for the graft loss of 3.85 (95% CI: 1.49-9.96; P = 0.005). CONCLUSIONS: In this study, anemia at 1 year was independently associated with death-censored graft survival and anemicpatients were 3.8-fold more likely to lose the graft.
Authors: B L Kasiske; M A Vazquez; W E Harmon; R S Brown; G M Danovitch; R S Gaston; D Roth; J D Scandling; G G Singer Journal: J Am Soc Nephrol Date: 2000-10 Impact factor: 10.121
Authors: G Fernández Fresnedo; R Palomar; E Rodrigo; J C Ruiz; A L M de Francisco; J G Cotorruelo; M Arias Journal: Transplant Proc Date: 2005-11 Impact factor: 1.066
Authors: Matthias Lorenz; Josef Kletzmayr; Agnes Perschl; Alexander Furrer; Walter H Hörl; Gere Sunder-Plassmann Journal: J Am Soc Nephrol Date: 2002-03 Impact factor: 10.121
Authors: Zhongli Huang; Turun Song; Lei Fu; Zhengsheng Rao; Dongyang Zeng; Yang Qiu; Xianding Wang; Libo Xie; Qiang Wei; Li Wang; Tao Lin Journal: Int Urol Nephrol Date: 2015-08-06 Impact factor: 2.370