Literature DB >> 21170260

Dinosaurs and ancient civilizations: reflections on the treatment of cancer.

Alnawaz Rehemtulla1.   

Abstract

Research efforts in the area of palaeopathology have been seen as an avenue to improve our understanding of the pathogenesis of cancer. Answers to questions of whether dinosaurs had cancer, or if cancer plagued ancient civilizations, have captured the imagination as well as the popular media. Evidence for dinosaurian cancer may indicate that cancer may have been with us from the dawn of time. Ancient recorded history suggests that past civilizations attempted to fight cancer with a variety of interventions. When contemplating the issue why a generalized cure for cancer has not been found, it might prove useful to reflect on the relatively limited time that this issue has been an agenda item of governmental attention as well as continued introduction of an every evolving myriad of manmade carcinogens relative to the total time cancer has been present on planet Earth. This article reflects on the history of cancer and the progress made following the initiation of the "era of cancer chemotherapy."

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Year:  2010        PMID: 21170260      PMCID: PMC3003131          DOI: 10.1593/neo.101588

Source DB:  PubMed          Journal:  Neoplasia        ISSN: 1476-5586            Impact factor:   5.715


  391 in total

1.  Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.

Authors:  Abraham Schneider; Rania H Younis; J Silvio Gutkind
Journal:  Neoplasia       Date:  2008-11       Impact factor: 5.715

2.  PI3K/Akt pathway activation attenuates the cytotoxic effect of methyl jasmonate toward sarcoma cells.

Authors:  Uri Elia; Eliezer Flescher
Journal:  Neoplasia       Date:  2008-11       Impact factor: 5.715

3.  Variant HNF1 modulates epithelial plasticity of normal and transformed ovary cells.

Authors:  Antonella Tomassetti; Giuseppina De Santis; Giancarlo Castellano; Silvia Miotti; Mimma Mazzi; Daniela Tomasoni; Frans Van Roy; Maria Luisa Carcangiu; Silvana Canevari
Journal:  Neoplasia       Date:  2008-12       Impact factor: 5.715

4.  WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis.

Authors:  Yahya Tamimi; Usukuma Ekuere; Nicholas Laughton; Paul Grundy
Journal:  Neoplasia       Date:  2008-12       Impact factor: 5.715

5.  Neoplasia: the second decade.

Authors:  Alnawaz Rehemtulla
Journal:  Neoplasia       Date:  2008-12       Impact factor: 5.715

6.  RET/PTC1-driven neoplastic transformation and proinvasive phenotype of human thyrocytes involve Met induction and beta-catenin nuclear translocation.

Authors:  Giuliana Cassinelli; Enrica Favini; Debora Degl'Innocenti; Alessandro Salvi; Giuseppina De Petro; Marco A Pierotti; Franco Zunino; Maria Grazia Borrello; Cinzia Lanzi
Journal:  Neoplasia       Date:  2009-01       Impact factor: 5.715

Review 7.  The story of human cytomegalovirus and cancer: increasing evidence and open questions.

Authors:  Martin Michaelis; Hans W Doerr; Jindrich Cinatl
Journal:  Neoplasia       Date:  2009-01       Impact factor: 5.715

8.  Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas.

Authors:  Ping Gu; Xiangbin Xing; Marc Tänzer; Christoph Röcken; Wilko Weichert; Audrius Ivanauskas; Matthias Pross; Ulrich Peitz; Peter Malfertheiner; Roland M Schmid; Matthias P A Ebert
Journal:  Neoplasia       Date:  2008-06       Impact factor: 5.715

9.  PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations.

Authors:  Katsuhiko Nosho; Takako Kawasaki; Mutsuko Ohnishi; Yuko Suemoto; Gregory J Kirkner; Dimity Zepf; Liying Yan; Janina A Longtine; Charles S Fuchs; Shuji Ogino
Journal:  Neoplasia       Date:  2008-06       Impact factor: 5.715

10.  A functionally significant cross-talk between androgen receptor and ErbB2 pathways in estrogen receptor negative breast cancer.

Authors:  Ali Naderi; Luke Hughes-Davies
Journal:  Neoplasia       Date:  2008-06       Impact factor: 5.715

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  4 in total

1.  The interconnectedness of cancer cell signaling.

Authors:  Alnawaz Rehemtulla
Journal:  Neoplasia       Date:  2011-12       Impact factor: 5.715

2.  Overcoming intratumor heterogeneity of polygenic cancer drug resistance with improved biomarker integration.

Authors:  Alnawaz Rehemtulla
Journal:  Neoplasia       Date:  2012-12       Impact factor: 5.715

Review 3.  Omics-based molecular techniques in oral pathology centred cancer: prospect and challenges in Africa.

Authors:  Henry A Adeola; Olujide O Soyele; Anthonio O Adefuye; Sikiru A Jimoh; Azeez Butali
Journal:  Cancer Cell Int       Date:  2017-06-05       Impact factor: 5.722

Review 4.  The occurrence of cancer in vertebrates: a mini review.

Authors:  Christos V Kitsoulis; Athanasios D Baxevanis; Theodore J Abatzopoulos
Journal:  J Biol Res (Thessalon)       Date:  2020-06-08       Impact factor: 1.889

  4 in total

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