Sir,I read with great interest a recent published work on triphala mouthwash by Tandon et al[1] They concluded that there was no significant difference between triphala and chlorhexidine mouthwashes.[1] I agree that this work confirms the dental usefulness of triphala. The previous report also mentioned the counteraction on biofilm formed on tooth substrate.[2] However, there are some facts on the triphala to be known. Triphala has been recently reported to have an in vitro effect on drug modulating enzymes.[3] Disturbance on cytochrome P450 is mentioned, thereby the likelihood of herb–drug interactions, if these are administered concomitantly, can be expected.[3]