OBJECTIVE: Detection of large cell transformation (LCT) has been reported with the increasing use of PET/computed tomography (CT) in patients with indolent lymphomas. However, there is little information on PET/CT characteristics, specifically, the distribution of lesion maximum standardized uptake value (SUV(max)) within a patient, or SUV(max) changes before and after LCT. Our objectives were to compare SUV(max) values and distribution between nontransformed and LCT patients; to compare SUV(max) of LCT and nontransformed lesions in patients with documented focal transformation; and to measure the SUV(max) changes in patients before and after LCT. METHODS: Retrospective study of patients with LCT (n=29)compared with nontransformed (n=41), and comparison of LCT and nontransformed lesions within patients and over time. RESULTS: On average, the highest SUV(max) was greater in LCT patients than in nontransformed patients. In addition, there was a wider range of SUV(max) values in the LCT group compared with the nontransformed group (P<0.05). The median ratio of the SUV(max) of 12 LCT to nontransformed biopsy-proven lesions in the same patient was 4.3, P value of less than 0.05 (range 2.6-15.5). In 10 of 12 patients it was greater than or equal to 3. No change in highest SUV(max) and distribution was shown on serial PET in untreated nontransformed patients. CONCLUSION: LCT is often focal and is associated with higher SUV(max) than nontransformed. The emergence of a focus with SUV(max) three times or higher than others on a single scan, or that has tripled or more in value on serial scans, should raise suspicion for LCT.
OBJECTIVE: Detection of large cell transformation (LCT) has been reported with the increasing use of PET/computed tomography (CT) in patients with indolent lymphomas. However, there is little information on PET/CT characteristics, specifically, the distribution of lesion maximum standardized uptake value (SUV(max)) within a patient, or SUV(max) changes before and after LCT. Our objectives were to compare SUV(max) values and distribution between nontransformed and LCTpatients; to compare SUV(max) of LCT and nontransformed lesions in patients with documented focal transformation; and to measure the SUV(max) changes in patients before and after LCT. METHODS: Retrospective study of patients with LCT (n=29)compared with nontransformed (n=41), and comparison of LCT and nontransformed lesions within patients and over time. RESULTS: On average, the highest SUV(max) was greater in LCTpatients than in nontransformed patients. In addition, there was a wider range of SUV(max) values in the LCT group compared with the nontransformed group (P<0.05). The median ratio of the SUV(max) of 12 LCT to nontransformed biopsy-proven lesions in the same patient was 4.3, P value of less than 0.05 (range 2.6-15.5). In 10 of 12 patients it was greater than or equal to 3. No change in highest SUV(max) and distribution was shown on serial PET in untreated nontransformed patients. CONCLUSION:LCT is often focal and is associated with higher SUV(max) than nontransformed. The emergence of a focus with SUV(max) three times or higher than others on a single scan, or that has tripled or more in value on serial scans, should raise suspicion for LCT.
Authors: Xin Wan; Wei Guo; Xingtong Wang; Jia Li; Yangzhi Zhao; Xiaomeng Feng; Ken H Young; Ou Bai Journal: Am J Cancer Res Date: 2022-08-15 Impact factor: 5.942
Authors: Farheen Mir; Sally F Barrington; Helen Brown; Tina Nielsen; Deniz Sahin; Michel Meignan; Judith Trotman Journal: Blood Date: 2020-04-09 Impact factor: 22.113
Authors: Paolo Strati; Mohamed Amin Ahmed; Nathan H Fowler; Loretta J Nastoupil; Felipe Samaniego; Luis E Fayad; Fredrick B Hagemeister; Jorge E Romaguera; Alma Rodriguez; Michael Wang; Jason R Westin; Chan Cheah; Mansoor Noorani; Lei Feng; Richard E Davis; Sattva S Neelapu Journal: Haematologica Date: 2019-10-10 Impact factor: 9.941