OBJECTIVES: Increased arterial wave reflection is a predictor of cardiovascular events and has been hypothesized to be a cofactor in the pathophysiology of heart failure. Whether increased wave reflection is inversely associated with left-ventricular (LV) systolic function in individuals without heart failure is not clear. METHODS: Arterial wave reflection and LV systolic function were assessed in 301 participants from the Cardiovascular Abnormalities and Brain Lesions (CABL) study using two-dimensional echocardiography and applanation tonometry of the radial artery to derive central arterial waveform by a validated transfer function. Aortic augmentation index (AIx) and wasted energy index (WEi) were used as indices of wave reflection. LV systolic function was measured by LV ejection fraction (LVEF) and tissue Doppler imaging (TDI). Mitral annulus peak systolic velocity (Sm), peak longitudinal strain and strain rate were measured. Participants with history of coronary artery disease, atrial fibrillation, LVEF less than 50% or wall motion abnormalities were excluded. RESULTS: Mean age of the study population was 68.3 ± 10.2 years (64.1% women, 65% hypertensive). LV systolic function by TDI was lower with increasing wave reflection, whereas LVEF was not. In multivariate analysis, TDI parameters of LV longitudinal systolic function were significantly and inversely correlated to AIx and WEi (P values from 0.05 to 0.002). CONCLUSIONS: In a community cohort without heart failure and with normal LVEF, an increased arterial wave reflection was associated with subclinical reduction in LV systolic function assessed by novel TDI techniques. Further studies are needed to investigate the prognostic implications of this relationship.
OBJECTIVES: Increased arterial wave reflection is a predictor of cardiovascular events and has been hypothesized to be a cofactor in the pathophysiology of heart failure. Whether increased wave reflection is inversely associated with left-ventricular (LV) systolic function in individuals without heart failure is not clear. METHODS: Arterial wave reflection and LV systolic function were assessed in 301 participants from the Cardiovascular Abnormalities and Brain Lesions (CABL) study using two-dimensional echocardiography and applanation tonometry of the radial artery to derive central arterial waveform by a validated transfer function. Aortic augmentation index (AIx) and wasted energy index (WEi) were used as indices of wave reflection. LV systolic function was measured by LV ejection fraction (LVEF) and tissue Doppler imaging (TDI). Mitral annulus peak systolic velocity (Sm), peak longitudinal strain and strain rate were measured. Participants with history of coronary artery disease, atrial fibrillation, LVEF less than 50% or wall motion abnormalities were excluded. RESULTS: Mean age of the study population was 68.3 ± 10.2 years (64.1% women, 65% hypertensive). LV systolic function by TDI was lower with increasing wave reflection, whereas LVEF was not. In multivariate analysis, TDI parameters of LV longitudinal systolic function were significantly and inversely correlated to AIx and WEi (P values from 0.05 to 0.002). CONCLUSIONS: In a community cohort without heart failure and with normal LVEF, an increased arterial wave reflection was associated with subclinical reduction in LV systolic function assessed by novel TDI techniques. Further studies are needed to investigate the prognostic implications of this relationship.
Authors: Neil L Greenberg; Michael S Firstenberg; Peter L Castro; Michael Main; Agnese Travaglini; Jill A Odabashian; Jeanne K Drinko; L Leonardo Rodriguez; James D Thomas; Mario J Garcia Journal: Circulation Date: 2002-01-01 Impact factor: 29.690
Authors: Frank Weidemann; Fadi Jamal; George R Sutherland; Piet Claus; Miroslaw Kowalski; Liv Hatle; Ivan De Scheerder; Bart Bijnens; Frank E Rademakers Journal: Am J Physiol Heart Circ Physiol Date: 2002-08 Impact factor: 4.733
Authors: Pairoj Rerkpattanapipat; W Gregory Hundley; Kerry M Link; Peter H Brubaker; Craig A Hamilton; Stephen N Darty; Timothy M Morgan; Dalane W Kitzman Journal: Am J Cardiol Date: 2002-12-01 Impact factor: 2.778
Authors: Alexandros P Patrianakos; Fragiskos I Parthenakis; Eva Nyktari; N Malliaraki; Dimitrios N Karakitsos; Panos E Vardas Journal: J Card Fail Date: 2009-05-21 Impact factor: 5.712
Authors: Zi Ye; Thais Coutinho; Patricia A Pellikka; Hector R Villarraga; Barry A Borlaug; Iftikhar J Kullo Journal: Am J Hypertens Date: 2015-04-03 Impact factor: 2.689
Authors: Cesare Russo; Fusako Sera; Zhezhen Jin; Vittorio Palmieri; Shunichi Homma; Tatjana Rundek; Mitchell S V Elkind; Ralph L Sacco; Marco R Di Tullio Journal: Eur J Heart Fail Date: 2016-04-24 Impact factor: 15.534
Authors: Nathan F Johnson; Brian T Gold; Alison L Bailey; Jody L Clasey; Jonathan G Hakun; Matthew White; Doug E Long; David K Powell Journal: Neuroimage Date: 2015-05-30 Impact factor: 6.556
Authors: Mads Ersbøll; Fawaz Al Enezi; Zainab Samad; Brenda Sedberry; Stephen H Boyle; Christopher O'Connor; Wei Jiang; Eric J Velazquez Journal: JACC Cardiovasc Imaging Date: 2014-03-13
Authors: Cesare Russo; Zhezhen Jin; Shunichi Homma; Tatjana Rundek; Mitchell S V Elkind; Ralph L Sacco; Marco R Di Tullio Journal: Am Heart J Date: 2015-02-21 Impact factor: 4.749
Authors: Cesare Russo; Zhezhen Jin; Shunichi Homma; Mitchell S V Elkind; Tatjana Rundek; Mitsuhiro Yoshita; Charles DeCarli; Clinton B Wright; Ralph L Sacco; Marco R Di Tullio Journal: Circulation Date: 2013-07-31 Impact factor: 29.690
Authors: Cesare Russo; Zhezhen Jin; Fusako Sera; Edward S Lee; Shunichi Homma; Tatjana Rundek; Mitchell S V Elkind; Ralph L Sacco; Marco R Di Tullio Journal: Circ Cardiovasc Imaging Date: 2015-08 Impact factor: 7.792