Literature DB >> 21169495

Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil.

Ryota Hidese1, Hisaaki Mihara, Tatsuo Kurihara, Nobuyoshi Esaki.   

Abstract

The reductive pyrimidine catabolic pathway is absent in Escherichia coli. However, the bacterium contains an enzyme homologous to mammalian dihydropyrimidine dehydrogenase. Here, we show that E. coli dihydropyrimidine dehydrogenase is the first member of a novel NADH-dependent subclass of iron-sulfur flavoenzymes catalyzing the conversion of uracil to 5,6-dihydrouracil in vivo.

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Year:  2010        PMID： 21169495      PMCID： PMC3028684          DOI： 10.1128/JB.01178-10

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

1.  Functional expression and characterization of the two cyclic amidohydrolase enzymes, allantoinase and a novel phenylhydantoinase, from Escherichia coli.

Authors:  G J Kim; D E Lee; H S Kim
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

2.  Isolation and characterization of an Escherichia coli B mutant strain defective in uracil catabolism.

Authors:  T P West
Journal:  Can J Microbiol       Date:  1998-11       Impact factor: 2.419

3.  Pyrimidine base catabolism in Pseudomonas putida biotype B.

Authors:  T P West
Journal:  Antonie Van Leeuwenhoek       Date:  2001-10       Impact factor: 2.271

4.  Purification and characterization of dihydropyrimidine dehydrogenase from Alcaligenes eutrophus.

Authors:  U Schmitt; K Jahnke; K Rosenbaum; P F Cook; K D Schnackerz
Journal:  Arch Biochem Biophys       Date:  1996-08-01       Impact factor: 4.013

5.  Properties and regulation of pyrimidine catabolism in Escherichia coli.

Authors:  S Simaga; E Kos
Journal:  Int J Biochem       Date:  1981

6.  Pyrimidine base and ribonucleoside utilization by the Pseudomonas alcaligenes group.

Authors:  T P West
Journal:  Antonie Van Leeuwenhoek       Date:  1991-05       Impact factor: 2.271

7.  Pyrimidine ribonucleoside catabolic enzyme activities of Pseudomonas pickettii.

Authors:  T P West
Journal:  Antonie Van Leeuwenhoek       Date:  1994       Impact factor: 2.271

8.  Dihydropyrimidine dehydrogenase: a flavoprotein with four iron-sulfur clusters.

Authors:  Klaus D Schnackerz; Doreen Dobritzsch; Ylva Lindqvist; Paul F Cook
Journal:  Biochim Biophys Acta       Date:  2004-09-01

9.  Pyrimidine catabolism in Pseudomonas aeruginosa.

Authors:  S Kim; T P West
Journal:  FEMS Microbiol Lett       Date:  1991-01-15       Impact factor: 2.742

10.  The protein-DNA contacts in RutR•carAB operator complexes.

Authors:  Phu Le Minh Nguyen; Indra Bervoets; Dominique Maes; Daniel Charlier
Journal:  Nucleic Acids Res       Date:  2010-05-14       Impact factor: 16.971
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  8 in total

1.  Global identification of genes affecting iron-sulfur cluster biogenesis and iron homeostasis.

Authors:  Ryota Hidese; Hisaaki Mihara; Tatsuo Kurihara; Nobuyoshi Esaki
Journal:  J Bacteriol       Date:  2014-01-10       Impact factor: 3.490

2.  Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.

Authors:  Peter Spanogiannopoulos; Than S Kyaw; Ben G H Guthrie; Patrick H Bradley; Joyce V Lee; Jonathan Melamed; Ysabella Noelle Amora Malig; Kathy N Lam; Daryll Gempis; Moriah Sandy; Wesley Kidder; Erin L Van Blarigan; Chloe E Atreya; Alan Venook; Roy R Gerona; Andrei Goga; Katherine S Pollard; Peter J Turnbaugh
Journal:  Nat Microbiol       Date:  2022-09-22       Impact factor: 30.964

3.  Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation.

Authors:  Olivier Finet; Carlo Yague-Sanz; Lara Katharina Krüger; Phong Tran; Valérie Migeot; Max Louski; Alicia Nevers; Mathieu Rougemaille; Jingjing Sun; Felix G M Ernst; Ludivine Wacheul; Maxime Wery; Antonin Morillon; Peter Dedon; Denis L J Lafontaine; Damien Hermand
Journal:  Mol Cell       Date:  2021-11-18       Impact factor: 19.328

Review 4.  The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function.

Authors:  Olivier Finet; Carlo Yague-Sanz; Florian Marchand; Damien Hermand
Journal:  RNA Biol       Date:  2022-01       Impact factor: 4.766

5.  A ferredoxin-dependent dihydropyrimidine dehydrogenase in Clostridium chromiireducens.

Authors:  Feifei Wang; Yifeng Wei; Qiang Lu; Ee Lui Ang; Huimin Zhao; Yan Zhang
Journal:  Biosci Rep       Date:  2020-07-31       Impact factor: 3.840

6.  Identifying reaction modules in metabolic pathways: bioinformatic deduction and experimental validation of a new putative route in purine catabolism.

Authors:  Matthieu Barba; Raphaël Dutoit; Christianne Legrain; Bernard Labedan
Journal:  BMC Syst Biol       Date:  2013-10-05

7.  Mirror, mirror on the wall: which microbiomes will help heal them all?

Authors:  Renuka R Nayak; Peter J Turnbaugh
Journal:  BMC Med       Date:  2016-05-04       Impact factor: 8.775

8.  iTRAQ-Based Proteomic Analysis of Sublethally Injured Escherichia coli O157:H7 Cells Induced by High Pressure Carbon Dioxide.

Authors:  Xiufang Bi; Yongtao Wang; Xiaosong Hu; Xiaojun Liao
Journal:  Front Microbiol       Date:  2017-12-18       Impact factor: 5.640
  8 in total

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