Biodegradable lysine diisocyanate-based poly(glycolide-co-epsilon-caprolactone)-urethane network in artificial skin.

A biodegradable lysine diisocyanate-based poly(glycolide-co-epsilon-caprolactone)urethane network has been evaluated as a material for the construction of a macroporous bottom layer (dermal analogue) in a two-layer artificial skin. High rates of in vitro degradation were observed; degradation of the porous poly(glycolide-co-epsilon-caprolactone)urethane networks was faster in vivo than in vitro. Subcutaneous implantation in guinea pigs showed that the porous polyurethane networks allowed rapid cell ingrowth, degraded almost completely 4-8 wk after implantation and evoked no adverse tissue reaction.