OBJECTIVE: To investigate whether proteins secreted in urine differ between women with and without endometriosis. DESIGN: Laboratory study using human urine. SETTING: University-based laboratory. PATIENT(S): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. INTERVENTION(S): Urine collection from women with and without endometriosis. MAIN OUTCOME MEASURE(S): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. RESULT(S): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. CONCLUSION(S): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.
OBJECTIVE: To investigate whether proteins secreted in urine differ between women with and without endometriosis. DESIGN: Laboratory study using human urine. SETTING: University-based laboratory. PATIENT(S): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. INTERVENTION(S): Urine collection from women with and without endometriosis. MAIN OUTCOME MEASURE(S): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. RESULT(S): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. CONCLUSION(S): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis.
Authors: Emily Liu; Vicki Nisenblat; Cindy Farquhar; Ian Fraser; Patrick M M Bossuyt; Neil Johnson; M Louise Hull Journal: Cochrane Database Syst Rev Date: 2015-12-23
Authors: Katherine E Williams; Olga Miroshnychenko; Eric B Johansen; Richard K Niles; Rajeshwari Sundaram; Kurunthachalam Kannan; Matthew Albertolle; Yan Zhou; Namrata Prasad; Penelope M Drake; Linda C Giudice; Steven C Hall; H Ewa Witkowska; Germaine M Buck Louis; Susan J Fisher Journal: J Proteomics Date: 2014-10-13 Impact factor: 4.044
Authors: Costin Vlad Anastasiu; Marius Alexandru Moga; Andrea Elena Neculau; Andreea Bălan; Ioan Scârneciu; Roxana Maria Dragomir; Ana-Maria Dull; Liana-Maria Chicea Journal: Int J Mol Sci Date: 2020-03-04 Impact factor: 5.923