Lorenzo Beretta1, Alessandro Santaniello. 1. Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Via Pace 9, Milan, Italy. lorberimm@hotmail.com
Abstract
BACKGROUND: The analysis of survival data allows to evaluate whether in a population the genetic exposure is related to the time until an event occurs. Owing to the complexity of common human diseases, there is the incipient need to develop bioinformatics tools to properly model non-linear high-order interactions in lifetime datasets. These tools, such as the survival dimensionality reduction algorithm, may suffer from extreme computational costs in large-scale datasets. Herein, we address the problem of estimating the quality of attributes, so as to extract relevant features from lifetime datasets and to scale down their size. METHODS: The ReliefF algorithm was modified and adjusted to compensate for the loss of information due to censoring, introducing reclassification and weighting schemes. Synthetic lifetime two-locus epistatic datasets of 500 attributes, 400-800 individuals and different degrees of cumulative heritability and censorship were generated. The capability of the survival ReliefF algorithm (sReliefF) and of a tuned sReliefF approach to properly select the causative pair of attributes was evaluated and compared to univariate selection based on Cox scores. RESULTS/ CONCLUSIONS: sReliefF methods efficiently scaled down the simulated datasets, whilst univariate selection performed no better than random choice. These approaches may help to reduce the computational cost and to improve the classification task of algorithms that model high-order interactions in presence of right-censored data. AVAILABILITY: http://sourceforge.net/projects/sdrproject/files/sReliefF/.
BACKGROUND: The analysis of survival data allows to evaluate whether in a population the genetic exposure is related to the time until an event occurs. Owing to the complexity of common human diseases, there is the incipient need to develop bioinformatics tools to properly model non-linear high-order interactions in lifetime datasets. These tools, such as the survival dimensionality reduction algorithm, may suffer from extreme computational costs in large-scale datasets. Herein, we address the problem of estimating the quality of attributes, so as to extract relevant features from lifetime datasets and to scale down their size. METHODS: The ReliefF algorithm was modified and adjusted to compensate for the loss of information due to censoring, introducing reclassification and weighting schemes. Synthetic lifetime two-locus epistatic datasets of 500 attributes, 400-800 individuals and different degrees of cumulative heritability and censorship were generated. The capability of the survival ReliefF algorithm (sReliefF) and of a tuned sReliefF approach to properly select the causative pair of attributes was evaluated and compared to univariate selection based on Cox scores. RESULTS/ CONCLUSIONS: sReliefF methods efficiently scaled down the simulated datasets, whilst univariate selection performed no better than random choice. These approaches may help to reduce the computational cost and to improve the classification task of algorithms that model high-order interactions in presence of right-censored data. AVAILABILITY: http://sourceforge.net/projects/sdrproject/files/sReliefF/.
Authors: Ryan J Urbanowicz; Melissa Meeker; William La Cava; Randal S Olson; Jason H Moore Journal: J Biomed Inform Date: 2018-07-18 Impact factor: 6.317