Literature DB >> 2116797

Mastoparan, a wasp venom, activates platelets via pertussis toxin-sensitive GTP-binding proteins.

Y Ozaki1, Y Matsumoto, Y Yatomi, M Higashihara, T Kariya, S Kume.   

Abstract

Mastoparan induced limited release of serotonin from intact human platelets, while neither intracellular calcium ion elevation nor arachidonic acid mobilization was observed. Cytolysis induced by mastoparan was negligible in the concentration range that induced serotonin release. In digitonin-permeabilized cells, mastoparan induced Ca(++)-independent release of serotonin and Ca(++)-dependent arachidonic acid release. Both serotonin release and arachidonic acid release were reduced by pertussis toxin, suggesting that platelet activation induced by mastoparan is mediated by GTP-binding proteins.

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Year:  1990        PMID： 2116797     DOI： 10.1016/0006-291x(90)92159-w

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

Review 1.  Venom effects on monoaminergic systems.

Authors:  Aviva Weisel-Eichler; Frederic Libersat
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2004-05-25       Impact factor: 1.836

2.  Characterization of a mastoparan-stimulated nucleotidase from bovine brain.

Authors:  B M Denker; P Tempst; E J Neer
Journal:  Biochem J       Date:  1991-09-01       Impact factor: 3.857

3.  Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking.

Authors:  Andrea S Rothmeier; Patrizia Marchese; Florian Langer; Yuichi Kamikubo; Florence Schaffner; Joseph Cantor; Mark H Ginsberg; Zaverio M Ruggeri; Wolfram Ruf
Journal:  Arterioscler Thromb Vasc Biol       Date:  2017-05-11       Impact factor: 8.311

4.  Mastoparan-induced phosphatidylcholine hydrolysis by phospholipase D activation in human astrocytoma cells.

Authors:  K Mizuno; N Nakahata; Y Ohizumi
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

5.  Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein.

Authors:  N Vitale; D Thiersé; D Aunis; M F Bader
Journal:  Biochem J       Date:  1994-05-15       Impact factor: 3.857

6.  Ca(2+)-independent fusion of synaptic vesicles with phospholipase A2-treated presynaptic membranes in vitro.

Authors:  H Nishio; T Takeuchi; F Hata; O Yagasaki
Journal:  Biochem J       Date:  1996-09-15       Impact factor: 3.857

7.  Effects of the amphiphilic peptides mastoparan and adenoregulin on receptor binding, G proteins, phosphoinositide breakdown, cyclic AMP generation, and calcium influx.

Authors:  Y Shin; R W Moni; J E Lueders; J W Daly
Journal:  Cell Mol Neurobiol       Date:  1994-04       Impact factor: 5.046

8.  Effects of mastoparan upon the late stages of the ACTH secretory pathway of AtT-20 cells.

Authors:  B W McFerran; S B Guild
Journal:  Br J Pharmacol       Date:  1995-06       Impact factor: 8.739

9.  Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor β1 (TGF-β1) activation.

Authors:  Teresa M Brophy; Barry S Coller; Jasimuddin Ahamed
Journal:  J Biol Chem       Date:  2013-03-05       Impact factor: 5.157

10.  Silymarin secretion and its elicitation by methyl jasmonate in cell cultures of Silybum marianum is mediated by phospholipase D-phosphatidic acid.

Authors:  Elena Madrid; Purificación Corchete
Journal:  J Exp Bot       Date:  2009-12-09       Impact factor: 6.992
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