Literature DB >> 21166500

Thrombin expression in prostate: a novel finding.

Manish Kohli1, Karin Williams, Jorge L Yao, Richard A Dennis, Jiaoti Huang, Jay Reeder, William A Ricke.   

Abstract

INTRODUCTION: A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue.
METHODS: Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by immunohistochemistry of prostate tissue microarrays.
RESULTS: (Pro)thrombin mRNA expression was detected in cancer tissue and localized to prostatic epithelium and stroma by ISH. Thrombin protein was detected in stroma of benign and malignant epithelium (p <.05).
CONCLUSIONS: Prostate tissue is a rich reservoir of thrombin. This may have potential for developing antithrombin-based cancer therapy.

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Year:  2011        PMID： 21166500      PMCID： PMC3136353          DOI： 10.3109/07357907.2010.535057

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  23 in total

1.  Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway.

Authors:  G J Miller; K A Bauer; D J Howarth; J A Cooper; S E Humphries; R D Rosenberg
Journal:  J Thromb Haemost       Date:  2004-12       Impact factor: 5.824

Review 2.  Pathways of coagulation/fibrinolysis activation in malignancy.

Authors:  L R Zacharski; M Z Wojtukiewicz; V Costantini; D L Ornstein; V A Memoli
Journal:  Semin Thromb Hemost       Date:  1992-01       Impact factor: 4.180

3.  Thrombin receptor-dependent prostaglandin E2 synthesis in hamster fibroblasts: synergistic interactions with interleukin-1beta.

Authors:  C K Derian; A J Eckardt
Journal:  Exp Cell Res       Date:  1997-04-10       Impact factor: 3.905

Review 4.  Activation of the coagulation system in cancerogenesis and metastasation.

Authors:  W Z Xie; M Leibl; M R Clark; P Dohrmann; T Kunze; F Gieseler
Journal:  Biomed Pharmacother       Date:  2005-04       Impact factor: 6.529

5.  Stage-specific characterization of the vascular endothelial growth factor axis in prostate cancer: expression of lymphangiogenic markers is associated with advanced-stage disease.

Authors:  Varsha Kaushal; Perkins Mukunyadzi; Richard A Dennis; Eric R Siegel; Donald E Johnson; Manish Kohli
Journal:  Clin Cancer Res       Date:  2005-01-15       Impact factor: 12.531

6.  Fibrin formation on vessel walls in hyperplastic and malignant prostate tissue.

Authors:  M Z Wojtukiewicz; L R Zacharski; V A Memoli; W Kisiel; B J Kudryk; T E Moritz; S M Rousseau; D C Stump
Journal:  Cancer       Date:  1991-03-01       Impact factor: 6.860

7.  Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism.

Authors:  Agnes Y Y Lee; Frederick R Rickles; Jim A Julian; Michael Gent; Ross I Baker; Chris Bowden; Ajay K Kakkar; Martin Prins; Mark N Levine
Journal:  J Clin Oncol       Date:  2005-02-07       Impact factor: 44.544

8.  Low molecular weight heparin, therapy with dalteparin, and survival in advanced cancer: the fragmin advanced malignancy outcome study (FAMOUS).

Authors:  Ajay K Kakkar; Mark N Levine; Zbigniew Kadziola; Nicholas R Lemoine; Vanessa Low; Heman K Patel; Gordon Rustin; Michael Thomas; Mary Quigley; Robin C N Williamson
Journal:  J Clin Oncol       Date:  2004-05-15       Impact factor: 44.544

9.  Cellular localization of enzymatically active thrombin in intact human tissues by hirudin binding.

Authors:  L R Zacharski; V A Memoli; W D Morain; J M Schlaeppi; S M Rousseau
Journal:  Thromb Haemost       Date:  1995-05       Impact factor: 5.249

10.  The MET oncogene drives a genetic programme linking cancer to haemostasis.

Authors:  Carla Boccaccio; Gabriella Sabatino; Enzo Medico; Flavia Girolami; Antonia Follenzi; Gigliola Reato; Antonino Sottile; Luigi Naldini; Paolo M Comoglio
Journal:  Nature       Date:  2005-03-17       Impact factor: 49.962
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  3 in total

1.  Candidate serum biomarkers for prostate adenocarcinoma identified by mRNA differences in prostate tissue and verified with protein measurements in tissue and blood.

Authors:  Eric W Klee; Olga P Bondar; Marcia K Goodmanson; Roy B Dyer; Sibel Erdogan; Eric J Bergstralh; H Robert Bergen; Thomas J Sebo; George G Klee
Journal:  Clin Chem       Date:  2012-01-12       Impact factor: 8.327

2.  Active thrombin produced by the intestinal epithelium controls mucosal biofilms.

Authors:  Jean-Paul Motta; Alexandre Denadai-Souza; David Sagnat; Laura Guiraud; Anissa Edir; Chrystelle Bonnart; Mireille Sebbag; Perrine Rousset; Ariane Lapeyre; Carine Seguy; Noa Mathurine-Thomas; Heather J Galipeau; Delphine Bonnet; Laurent Alric; Andre G Buret; John L Wallace; Antoine Dufour; Elena F Verdu; Morley D Hollenberg; Eric Oswald; Matteo Serino; Celine Deraison; Nathalie Vergnolle
Journal:  Nat Commun       Date:  2019-07-19       Impact factor: 14.919

Review 3.  Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue.

Authors:  Ibrahim AlZaim; Aya Al-Saidi; Safaa H Hammoud; Nadine Darwiche; Yusra Al-Dhaheri; Ali H Eid; Ahmed F El-Yazbi
Journal:  Cancers (Basel)       Date:  2022-03-25       Impact factor: 6.639
  3 in total

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