Literature DB >> 21165432

Effects of human defensin-α(1)on Trypanosoma cruzi trypomastigotes in vitro.

Yu E Kleschenko1, L P Karpenko, F Villalta.   

Abstract

Human defensin-α(1)is a biologically active peptide exhibiting a dose-dependent trypanocidal effect in vitro against trypomastigotes and amastigotes of Trypanosoma cruzi line Tulahuen. This effect is determined by fragmentation of parasite DNA reducing the capacity of passaged T. cruzi to invade HeLa cells.

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Year:  2010        PMID： 21165432      PMCID： PMC3053382          DOI： 10.1007/s10517-010-1038-5

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  9 in total

1.  The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations.

Authors:  B Agerberth; J Charo; J Werr; B Olsson; F Idali; L Lindbom; R Kiessling; H Jörnvall; H Wigzell; G H Gudmundsson
Journal:  Blood       Date:  2000-11-01       Impact factor: 22.113

Review 2.  Defensins: antimicrobial peptides of innate immunity.

Authors:  Tomas Ganz
Journal:  Nat Rev Immunol       Date:  2003-09       Impact factor: 53.106

Review 3.  Multispecific myeloid defensins.

Authors:  Robert I Lehrer
Journal:  Curr Opin Hematol       Date:  2007-01       Impact factor: 3.284

4.  Posttranslational processing of defensins in immature human myeloid cells.

Authors:  E V Valore; T Ganz
Journal:  Blood       Date:  1992-03-15       Impact factor: 22.113

Review 5.  Defensins: antimicrobial and cytotoxic peptides of mammalian cells.

Authors:  R I Lehrer; A K Lichtenstein; T Ganz
Journal:  Annu Rev Immunol       Date:  1993       Impact factor: 28.527

6.  The cysteine-cysteine family of chemokines RANTES, MIP-1alpha, and MIP-1beta induce trypanocidal activity in human macrophages via nitric oxide.

Authors:  F Villalta; Y Zhang; K E Bibb; J C Kappes; M F Lima
Journal:  Infect Immun       Date:  1998-10       Impact factor: 3.441

7.  Human defensin alpha-1 causes Trypanosoma cruzi membrane pore formation and induces DNA fragmentation, which leads to trypanosome destruction.

Authors:  M Nia Madison; Yuliya Y Kleshchenko; Pius N Nde; Kaneatra J Simmons; Maria F Lima; Fernando Villalta
Journal:  Infect Immun       Date:  2007-07-16       Impact factor: 3.441

8.  Trypanosoma cruzi trypomastigote clones differentially express a parasite cell adhesion molecule.

Authors:  M F Lima; F Villalta
Journal:  Mol Biochem Parasitol       Date:  1989-03-01       Impact factor: 1.759

9.  HeLa cells extend and internalize pseudopodia during active invasion by Trypanosoma cruzi trypomastigotes.

Authors:  S Schenkman; R A Mortara
Journal:  J Cell Sci       Date:  1992-04       Impact factor: 5.285
  9 in total
  2 in total

1.  Rhodnius prolixus interaction with Trypanosoma rangeli: modulation of the immune system and microbiota population.

Authors:  Cecilia S Vieira; Débora P Mattos; Peter J Waniek; Jayme M Santangelo; Marcela B Figueiredo; Marcia Gumiel; Fabio F da Mota; Daniele P Castro; Eloi S Garcia; Patrícia Azambuja
Journal:  Parasit Vectors       Date:  2015-03-01       Impact factor: 3.876

2.  Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients.

Authors:  Jialian Zhao; Qiang Gu; Lifeng Wang; Weize Xu; Lihua Chu; Ya Wang; Zhongwang Li; Shuijing Wu; Jianguo Xu; Zhiyong Hu; Qiang Shu; Xiangming Fang
Journal:  Mediators Inflamm       Date:  2018-05-22       Impact factor: 4.711
  2 in total

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