Literature DB >> 21165416

Monitoring of motor disorders in 7-day-old rats with severe hypoxic-ischemic injury of the brain.

A V Karasev1, S V Lebedev, T V Garats, A M Sharibzhanova, A V Makarov, N N Volodin, V P Chekhonin.   

Abstract

Seven-day old rats were subjected to unilateral ligation of the common carotid artery followed by 2-h exposure to a gas mixture consisting of 8% oxygen and 92% nitrogen. Locomotor function of rats was monitored weekly. Functional deficit in these animals persisted for at least 3 months. The exercise tests of rotarod, hanging, and narrowing track were most informative. Our results can be used in preclinical studies of new drugs for the therapy of perinatal brain injury.

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Year:  2010        PMID: 21165416     DOI: 10.1007/s10517-010-1022-0

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN: 0007-4888            Impact factor:   0.804


  2 in total

1.  Effect of creatine monohydrate supplementation on various hematological and serum biochemical parameters of male albino mice following neonatal hypoxia-ischemia encephalopathy.

Authors:  Shahid Iqbal; Nabia Nazir; Quratulane Gillani; Atif Akbar; Furhan Iqbal
Journal:  ScientificWorldJournal       Date:  2013-09-19

2.  Progesterone attenuates cerebral edema in neonatal rats with hypoxic-ischemic brain damage by inhibiting the expression of matrix metalloproteinase-9 and aquaporin-4.

Authors:  Xiaoyin Wang; Junhe Zhang; Yuxin Yang; Weihua Dong; Fang Wang; Li Wang; Xiaojuan Li
Journal:  Exp Ther Med       Date:  2013-05-15       Impact factor: 2.447

  2 in total

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