Effect of Lactobacillus casei 114001 probiotic on bioactivity of rutin.

Male Wistar rats were maintained for 2 weeks on a semisynthetic ration with 0.4% rutin or on the same ration with 0.4% rutin and Lactobacillus casei 11,4001 suspension in physiological saline in a dose of 2 x 10⁹ CFU per rat. Addition of Lactobacillus casei 114001 potentiated biological activity of rutin. Its antioxidant efficiency increased due to more pronounced increase in antioxidant capacity of the plasma, decrease in plasma content of LPO products, and more pronounced increase in reducing activity and antioxidant capacity of the cytosol of the liver and intestinal mucosa. The probiotic sharply increased the capacity of rutin to suppress pro carcinogenic activity of bacterial β-glucuronidase.