OBJECTIVE: We prospectively evaluated the rate of postnatal cytomegalovirus (CMV) transmission through breast milk in extremely premature infants to address the impact of CMV infection on preterm infants during lactation. STUDY DESIGN: A total of 25 mothers and 27 infants (two sets of twins) with birth weights <1000 g and/or gestational ages <28 weeks were enrolled in the study. They were mostly fed frozen-thawed breast milk. Breast milk, serum and urine samples were collected every 2 weeks and screened for CMV infection using the real-time polymerase chain reaction. RESULT: All of the 21 CMV-seropositive mothers had detectable CMV DNA in their breast milk, with a peak at 4 to 6 weeks postpartum. CMV infection was confirmed in only one infant (4.3%) who displayed almost no clinical symptoms. CONCLUSION: At our institutes, we mainly use frozen-thawed breast milk. We found low CMV transmission rates even in extremely premature infants, and the CMV-positive infant did not develop serious symptoms.
OBJECTIVE: We prospectively evaluated the rate of postnatal cytomegalovirus (CMV) transmission through breast milk in extremely premature infants to address the impact of CMV infection on preterm infants during lactation. STUDY DESIGN: A total of 25 mothers and 27 infants (two sets of twins) with birth weights <1000 g and/or gestational ages <28 weeks were enrolled in the study. They were mostly fed frozen-thawed breast milk. Breast milk, serum and urine samples were collected every 2 weeks and screened for CMV infection using the real-time polymerase chain reaction. RESULT: All of the 21 CMV-seropositive mothers had detectable CMV DNA in their breast milk, with a peak at 4 to 6 weeks postpartum. CMV infection was confirmed in only one infant (4.3%) who displayed almost no clinical symptoms. CONCLUSION: At our institutes, we mainly use frozen-thawed breast milk. We found low CMV transmission rates even in extremely premature infants, and the CMV-positive infant did not develop serious symptoms.
Authors: Elizabeth P Ehlinger; Emily M Webster; Helen H Kang; Aislyn Cangialose; Adam C Simmons; Kimberly H Barbas; Sandra K Burchett; Mary L Gregory; Karen M Puopolo; Karen P Puopolo; Sallie R Permar Journal: J Infect Dis Date: 2011-10-07 Impact factor: 5.226
Authors: Shannon A Ross; Marian G Michaels; Amina Ahmed; April L Palmer; Pablo J Sánchez; David I Bernstein; Kristina Feja; Audra Stewart; Suresh B Boppana; Karen B Fowler Journal: J Infect Dis Date: 2018-04-23 Impact factor: 5.226
Authors: Tatiana M Lanzieri; Sheila C Dollard; Cassandra D Josephson; D Scott Schmid; Stephanie R Bialek Journal: Pediatrics Date: 2013-05-27 Impact factor: 7.124
Authors: Matthew S Kelly; Daniel K Benjamin; Karen M Puopolo; Matthew M Laughon; Reese H Clark; Sagori Mukhopadhyay; Daniel K Benjamin; P Brian Smith; Sallie R Permar Journal: JAMA Pediatr Date: 2015-12-07 Impact factor: 26.796