OBJECTIVE: To describe relevant pathogen-related characteristics and their impact on sepsis pathogenesis and prognosis. DATA SOURCE: Current literature regarding genomic bacterial load and virulence factors, with an emphasis on the impact of these factors on pathophysiology and prognosis of sepsis. DATA EXTRACTION AND SYNTHESIS: The current paradigm on sepsis pathophysiology and management overlooks aspects concerning the nature and characteristics of the infecting pathogen. Our findings suggest that evaluation of genomic bacterial load might be useful to assess severity and predict prognosis in septic patients; its use during treatment for monitoring clinical response is another interesting potential application. Virulence factors identification might help to develop pathogen-specific therapeutic strategies for higher-risk septic patients. CONCLUSIONS: The recognition of the importance of quantifying the pathogen has major clinical implications and will open up a new field of exploration of therapies targeted at anticipating development and appropriate treatment in severe sepsis. The improved detection and understanding of bacterial virulence factors may lead to specific therapies.
OBJECTIVE: To describe relevant pathogen-related characteristics and their impact on sepsis pathogenesis and prognosis. DATA SOURCE: Current literature regarding genomic bacterial load and virulence factors, with an emphasis on the impact of these factors on pathophysiology and prognosis of sepsis. DATA EXTRACTION AND SYNTHESIS: The current paradigm on sepsis pathophysiology and management overlooks aspects concerning the nature and characteristics of the infecting pathogen. Our findings suggest that evaluation of genomic bacterial load might be useful to assess severity and predict prognosis in septic patients; its use during treatment for monitoring clinical response is another interesting potential application. Virulence factors identification might help to develop pathogen-specific therapeutic strategies for higher-risk septic patients. CONCLUSIONS: The recognition of the importance of quantifying the pathogen has major clinical implications and will open up a new field of exploration of therapies targeted at anticipating development and appropriate treatment in severe sepsis. The improved detection and understanding of bacterial virulence factors may lead to specific therapies.
Authors: Lauren Page Black; Michael A Puskarich; Morgan Henson; Taylor Miller; Srinivasa T Reddy; Rosemarie Fernandez; Faheem W Guirgis Journal: J Intensive Care Med Date: 2020-06-24 Impact factor: 2.889
Authors: Jason Phua; Wang Ngerng; Kay See; Chee Tay; Timothy Kiong; Hui Lim; Mei Chew; Hwee Yip; Adeline Tan; Haji Khalizah; Rolando Capistrano; Kang Lee; Amartya Mukhopadhyay Journal: Crit Care Date: 2013-09-12 Impact factor: 9.097
Authors: Marre van den Brand; Frank A M van den Dungen; Martine P Bos; Mirjam M van Weissenbruch; A Marceline van Furth; Annemieke de Lange; Anna Rubenjan; Remco P H Peters; Paul H M Savelkoul Journal: Crit Care Date: 2018-04-22 Impact factor: 9.097
Authors: Qin Lu; Philippe Eggimann; Charles-Edouard Luyt; Michel Wolff; Michael Tamm; Bruno François; Emmanuelle Mercier; Jorge Garbino; Pierre-François Laterre; Holger Koch; Verena Gafner; Michael P Rudolf; Erkan Mus; Antonio Perez; Hedvika Lazar; Jean Chastre; Jean-Jacques Rouby Journal: Crit Care Date: 2014-01-15 Impact factor: 9.097