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Literature DB >> 2116390

lck suppresses gene expression from various promoters including human T-cell leukemia virus type I promoter.

Abstract

The T-lymphocyte-specific tyrosine kinase gene, lck, is expressed in T-lymphocyte cell lines, except for several human T-cell leukemia virus type I(HTLV-I)-transformed T-lymphocyte cell lines, which produce HTLV-I. By introducing an lck-expression vector, we found that lck product suppresses gene expression from HTLV-I promoter in a transient assay. Moreover, various other promoters of cellular genes or viruses were found to have their transcriptional activity repressed by lck.

Entities: CellLine Chemical Disease Gene Species

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Year: 1990 PMID： 2116390 PMCID： PMC5918062 DOI： 10.1111/j.1349-7006.1990.tb02588.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

human T‐cell leukemia virus adult T‐cell leukemia long terminal repeat chloramphenicolacetyltransferase

33 in total

1. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.

Authors: J D Marth; R Peet; E G Krebs; R M Perlmutter
Journal: Cell Date: 1985-12 Impact factor: 41.582

2. Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion.

Authors: A F Voronova; B M Sefton
Journal: Nature Date: 1986 Feb 20-26 Impact factor: 49.962

3. A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.

Authors: Y Koga; N Caccia; B Toyonaga; R Spolski; Y Yanagi; Y Yoshikai; T W Mak
Journal: Eur J Immunol Date: 1986-12 Impact factor: 5.532

4. Translational activation of the lck proto-oncogene.

Authors: J D Marth; R W Overell; K E Meier; E G Krebs; R M Perlmutter
Journal: Nature Date: 1988-03-10 Impact factor: 49.962

5. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

Authors: M Maruyama; H Shibuya; H Harada; M Hatakeyama; M Seiki; T Fujita; J Inoue; M Yoshida; T Taniguchi
Journal: Cell Date: 1987-01-30 Impact factor: 41.582

6. Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription.

Authors: K Shimotohno; M Takano; T Teruuchi; M Miwa
Journal: Proc Natl Acad Sci U S A Date: 1986-11 Impact factor: 11.205

lck suppresses gene expression from various promoters including human T-cell leukemia virus type I promoter.

1. A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.

2. Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion.

3. A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.

4. Translational activation of the lck proto-oncogene.

5. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

6. Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription.

7. Powerful and versatile enhancer-promoter unit for mammalian expression vectors.

8. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck.

9. Two lck transcripts containing different 5' untranslated regions are present in T cells.

10. Human T lymphocytes express a protein-tyrosine kinase homologous to p56LSTRA.

Review 1. Mechanisms of T-cell activation by human T-cell lymphotropic virus type I.