OBJECTIVES: We sought to assess the association between the presence of a septal pouch in the left atrium and ischemic stroke. BACKGROUND: It has been suggested that the presence of a left septal pouch (LSP) may favor the stasis of blood and possibly result in thromboembolic complications. However, the embolic potential of an LSP is not known. METHODS: The association between an LSP and risk of stroke was assessed using a population-based case-control study design. The presence of an LSP was assessed by transesophageal echocardiography in 187 patients >50 years of age with a first-ever ischemic stroke (96 men, mean age 70.6 ± 9.0 years) and in 157 control subjects matched to patients by age, sex, and race/ethnicity. The association between an LSP and risk of stroke was assessed after adjustment for other stroke risk factors. RESULTS: Patients with LSPs were younger than control subjects (67.5 ± 9.1 years vs. 69.6 ± 8.8 years; p = 0.046), with a lower prevalence of hypertension (68.0% vs. 80.3%; p = 0.01). There were no differences in the prevalence of LSPs between stroke patients and control subjects (28.9% vs. 29.3%, respectively; p = 0.93). The subgroup of 69 patients (36.9%) with cryptogenic stroke showed a similar prevalence of LSPs (31.9% vs. 29.3%; p = 0.70). Multivariable analysis showed that the presence of an LSP was not associated with ischemic stroke (odds ratio: 1.09; 95% confidence interval: 0.64 to 1.85) or cryptogenic stroke (odds ratio: 1.41; 95% confidence interval: 0.71 to 2.78). CONCLUSIONS: This study does not demonstrate evidence of the association of the presence of an LSP with ischemic stroke or cryptogenic stroke. The stroke risk associated with LSPs requires further evaluation in the younger stroke populations. The cofactors that may turn an LSP from an innocent bystander to a causative mechanism for stroke remains to be elucidated.
OBJECTIVES: We sought to assess the association between the presence of a septal pouch in the left atrium and ischemic stroke. BACKGROUND: It has been suggested that the presence of a left septal pouch (LSP) may favor the stasis of blood and possibly result in thromboembolic complications. However, the embolic potential of an LSP is not known. METHODS: The association between an LSP and risk of stroke was assessed using a population-based case-control study design. The presence of an LSP was assessed by transesophageal echocardiography in 187 patients >50 years of age with a first-ever ischemic stroke (96 men, mean age 70.6 ± 9.0 years) and in 157 control subjects matched to patients by age, sex, and race/ethnicity. The association between an LSP and risk of stroke was assessed after adjustment for other stroke risk factors. RESULTS:Patients with LSPs were younger than control subjects (67.5 ± 9.1 years vs. 69.6 ± 8.8 years; p = 0.046), with a lower prevalence of hypertension (68.0% vs. 80.3%; p = 0.01). There were no differences in the prevalence of LSPs between strokepatients and control subjects (28.9% vs. 29.3%, respectively; p = 0.93). The subgroup of 69 patients (36.9%) with cryptogenic stroke showed a similar prevalence of LSPs (31.9% vs. 29.3%; p = 0.70). Multivariable analysis showed that the presence of an LSP was not associated with ischemic stroke (odds ratio: 1.09; 95% confidence interval: 0.64 to 1.85) or cryptogenic stroke (odds ratio: 1.41; 95% confidence interval: 0.71 to 2.78). CONCLUSIONS: This study does not demonstrate evidence of the association of the presence of an LSP with ischemic stroke or cryptogenic stroke. The stroke risk associated with LSPs requires further evaluation in the younger stroke populations. The cofactors that may turn an LSP from an innocent bystander to a causative mechanism for stroke remains to be elucidated.
Authors: P Lechat; J L Mas; G Lascault; P Loron; M Theard; M Klimczac; G Drobinski; D Thomas; Y Grosgogeat Journal: N Engl J Med Date: 1988-05-05 Impact factor: 91.245
Authors: Paulina E Gąsiorek; Maciej Banach; Marek Maciejewski; Andrzej Głąbiński; Aleksandra Paduszyńska; Jacek Rysz; Agata Bielecka-Dąbrowa Journal: Cardiol J Date: 2018-05-02 Impact factor: 2.737
Authors: Jonathan M Wong; Dawn M Lombardo; Ailin Barseghian; Jashdeep Dhoot; Harkawal S Hundal; Jonathan Salcedo; Annlia Paganini-Hill; Nathan D Wong; Mark Fisher Journal: Front Neurol Date: 2015-03-24 Impact factor: 4.003
Authors: Esmeralci Ferreira; Dinaldo Cavalcanti de Oliveira; Andressa Braga Barros; Valerio Fuks; Ângelo Antunes Salgado; Márcio José Montenegro da Costa; Sara Cristine Marques Dos Santos; Ivana Aragão; Márcia Bueno Castier; Luiz Kohn; Ricardo Mourilhe-Rocha; Felipe N Albuquerque; Roberto Esporcatte; Denilson Campos de Albuquerque Journal: Am J Case Rep Date: 2021-12-20
Authors: David Zisa; Francesco F Faletra; Benjamin S Wessler; Neil J Halin; Pranitha Reddy; Ayan R Patel; Natesa G Pandian Journal: CASE (Phila) Date: 2019-12-04