Pertussis: should we improve intensive care management or vaccination strategies?

Bordetella pertussis, responsible for one of the oldest vaccine-preventable diseases in children, has resurged in North America, Europe, Latin America and many countries around the world. Despite new recommended vaccination strategies for adolescents, pregnant women and adults, mortality is still significant in developing and developed countries. For the critical care management of the infant with pertussis, strategies include conventional ventilation, high-frequency oscillatory ventilation, extracorporeal membrane oxygenation, inhaled nitric oxygen, exchange transfusion, plasmapheresis and, more recently, leukodepletion. The paper under evaluation describes the experience of UK investigators in the management of pertussis with rapid leukodepletion for infants with extreme leukocytosis. Using this strategy, a rapid fall in the number of leukocytes was observed in these patients. Their results suggest that rapid leukodepletion should be considered in severely ill infants with pertussis and severe leukocytosis.