OBJECTIVES: To determine the seroprevalence of Mycoplasma pneumoniae infection among HIV infected children. Also, to correlate various hematological and radiological findings associated with M.pneumoniae infection. METHODS: This prospective hospital based study enrolled a total of 90 HIV seropositive children presenting with acute pulmonary symptoms, admitted to Pediatric ward of Karnataka Institute of Medical Sciences Hospital, Hubli. Patients underwent a thorough physical and radiological examination. IgM ELISA was used to detect specific antibodies against M. pneumoniae. Complete hemogram, liver function tests and CD4 counts were performed for correlation. RESULTS: IgM antibodies specific to M.pneumoniae was detected in 29(32.2%) children. Basal pneumonitis and hilar lymphadenopathy were common radiological findings seen in 11(37.4%) and 7(23.8%) respectively. Typical unilateral interstitial infiltration was seen only in 5(17%) children. Majority 27(93%) of M.pneumoniae infected cases were found anemic. Elevated AST levels were observed in 17(58.6%) of cases. Majority 18 (62%) of children with M.pneumoniae infection were immunosuppressed and the mean CD4% amongst them was 13.9 ± 6.4%. CONCLUSIONS: The prevalence of M.pneumoniae infection among HIV seropositive children with respiratory tract infection in the present study is 32.2%. Early detection of M.pneumoniae infection and prompt initiation of therapy may halt further depletion of CD4 cells and rapid progression to AIDS in these patients.
OBJECTIVES: To determine the seroprevalence of Mycoplasma pneumoniae infection among HIV infectedchildren. Also, to correlate various hematological and radiological findings associated with M.pneumoniae infection. METHODS: This prospective hospital based study enrolled a total of 90 HIV seropositive children presenting with acute pulmonary symptoms, admitted to Pediatric ward of Karnataka Institute of Medical Sciences Hospital, Hubli. Patients underwent a thorough physical and radiological examination. IgM ELISA was used to detect specific antibodies against M. pneumoniae. Complete hemogram, liver function tests and CD4 counts were performed for correlation. RESULTS: IgM antibodies specific to M.pneumoniae was detected in 29(32.2%) children. Basal pneumonitis and hilar lymphadenopathy were common radiological findings seen in 11(37.4%) and 7(23.8%) respectively. Typical unilateral interstitial infiltration was seen only in 5(17%) children. Majority 27(93%) of M.pneumoniae infected cases were found anemic. Elevated AST levels were observed in 17(58.6%) of cases. Majority 18 (62%) of children with M.pneumoniae infection were immunosuppressed and the mean CD4% amongst them was 13.9 ± 6.4%. CONCLUSIONS: The prevalence of M.pneumoniae infection among HIV seropositive children with respiratory tract infection in the present study is 32.2%. Early detection of M.pneumoniae infection and prompt initiation of therapy may halt further depletion of CD4 cells and rapid progression to AIDS in these patients.
Authors: J W Dorigo-Zetsma; S A Zaat; P M Wertheim-van Dillen; L Spanjaard; J Rijntjes; G van Waveren; J S Jensen; A F Angulo; J Dankert Journal: J Clin Microbiol Date: 1999-01 Impact factor: 5.948
Authors: E M Shankar; S Rajasekaran; Usha Anand Rao; P Paramesh; R Krishnakumar; R Rajan; H Kownhar Journal: Indian J Med Res Date: 2005-12 Impact factor: 2.375
Authors: S Lockman; N Hone; T A Kenyon; M Mwasekaga; M Villauthapillai; T Creek; E Zell; A Kirby; W L Thacker; D Talkington; I N Moura; N J Binkin; L Clay; J W Tappero Journal: Int J Tuberc Lung Dis Date: 2003-08 Impact factor: 2.373