RATIONALE: Valproate is widely used in the treatment of epilepsy, bipolar disorder, and chronic pain disorders, but its exact mechanisms of action is still incompletely understood. OBJECTIVES: Here we used transcranial magnetic stimulation to explore effects of a single dose of 800 mg valproate on motor cortex excitability in healthy volunteers. METHODS: Motor threshold, peripheral maximum M-wave, cortical silent period short intracortical inhibition, intracortical facilitation, and motor evoked potential recruitment were assessed before and 1.5 h after the administration of valproate in 15 (eight male, seven female) healthy volunteers. RESULTS: None of the measures of cortical excitability were found to be altered significantly after valproate. CONCLUSION: These results are in line with previous findings of unaffected intracortical excitability after a single dose of valproate, suggesting that valproate's immediate in vivo actions do not resemble the effects of classic GABAergic compounds.
RATIONALE: Valproate is widely used in the treatment of epilepsy, bipolar disorder, and chronic pain disorders, but its exact mechanisms of action is still incompletely understood. OBJECTIVES: Here we used transcranial magnetic stimulation to explore effects of a single dose of 800 mg valproate on motor cortex excitability in healthy volunteers. METHODS: Motor threshold, peripheral maximum M-wave, cortical silent period short intracortical inhibition, intracortical facilitation, and motor evoked potential recruitment were assessed before and 1.5 h after the administration of valproate in 15 (eight male, seven female) healthy volunteers. RESULTS: None of the measures of cortical excitability were found to be altered significantly after valproate. CONCLUSION: These results are in line with previous findings of unaffected intracortical excitability after a single dose of valproate, suggesting that valproate's immediate in vivo actions do not resemble the effects of classic GABAergic compounds.
Authors: Xingbao Li; Raffaella Ricci; Charles H Large; Berry Anderson; Ziad Nahas; Mark S George Journal: J Neural Transm (Vienna) Date: 2009-02-24 Impact factor: 3.575
Authors: Titia Q Ruijs; Jules A A C Heuberger; Annika A de Goede; Dimitrios Ziagkos; Marije E Otto; Robert J Doll; Michel J A M van Putten; Geert Jan Groeneveld Journal: Br J Clin Pharmacol Date: 2022-02-03 Impact factor: 3.716
Authors: T Hebel; M A Abdelnaim; M Deppe; P M Kreuzer; A Mohonko; T B Poeppl; R Rupprecht; B Langguth; M Schecklmann Journal: Eur Arch Psychiatry Clin Neurosci Date: 2021-07-03 Impact factor: 5.270