Literature DB >> 21161041

Effect of NO inhibitors on hypovolemic shock-induced hypotension.

S Ya Proskurjakov1, M V Filimonova, O N Borovaya, N G Kucherenko, A I Trishkina, L V Shteyn, V G Skvortsov, L P Ul'yanova, L I Shevchenko, Yu G Verkhovsky.   

Abstract

In vivo effect of isothiourea derivatives on NO production was studied by the method of electron paramagnetic resonance spectroscopy with a spin trap. We evaluated the influence of these compounds on hemodynamic parameters in anesthetized rats with hypovolemic shock. A correlation was found between the size of S,N-substituents in isothiourea derivatives (methyl, ethyl, and isopropyl) and NO inhibitory activity of compounds. The antihypotensive effect was more pronounced in compounds with high NO inhibitory activity containing the isopropyl radical.

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Year:  2010        PMID： 21161041     DOI： 10.1007/s10517-010-1057-2

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  1-Isobutanoil-2-isopropylisothiourea Phosphate, T1082: A Safe and Effective Prevention of Radiotherapy Complications in Oncology.

Authors:  Marina Filimonova; Alina Saburova; Ljudmila Shevchenko; Victoria Makarchuk; Anna Shitova; Olga Soldatova; Vitaly Rybachuk; Alexander Kosachenko; Kirill Nikolaev; Grigory Demyashkin; Vyacheslav Saburov; Sergey Koryakin; Petr Shegay; Andrey Kaprin; Sergey Ivanov; Alexander Filimonov
Journal:  Int J Mol Sci       Date:  2022-02-28       Impact factor: 5.923

2.  Preclinical studies of NOS inhibitor T1059 vasopressor activity on the models of acute hemorrhagic shock in rats and dogs.

Authors:  Marina Filimonova; Ljudmila Shevchenko; Victoria Makarchuk; Alina Saburova; Petr Shegay; Andrey Kaprin; Sergey Ivanov; Alexander Filimonov
Journal:  Front Pharmacol       Date:  2022-09-30       Impact factor: 5.988
  2 in total

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