Literature DB >> 21161036

Role of nitric oxide in activity control of mechanically gated ionic channels in cardiomyocytes: NO-donor study.

V E Kazanski1, A G Kamkin, E Yu Makarenko, N N Lysenko, P V Sutiagin, Tian Bo, I S Kiseleva.   

Abstract

Whole-cell ionic currents through mechanically gated channels (MGC) were recorded in isolated cardiomyocytes under voltage clamp conditions. In unstrained cells, NO donors SNAP and DEA-NO activated MGC and induced MG-like currents. In contrast, in stretched cells with activated MGC, these NO-donors inactivated and inhibited MGC.

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Year:  2010        PMID： 21161036     DOI： 10.1007/s10517-010-1052-7

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  2 in total

1.  TNF-α provokes electrical abnormalities in rat atrial myocardium via a NO-dependent mechanism.

Authors:  Denis V Abramochkin; Vladislav S Kuzmin; Vadim M Mitrochin; Leonid Kalugin; Anton Dvorzhak; Ekaterina Y Makarenko; Rudolf Schubert; Andre Kamkin
Journal:  Pflugers Arch       Date:  2013-07-05       Impact factor: 3.657

2.  The role of activation of two different sGC binding sites by NO-dependent and NO-independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes.

Authors:  Andre G Kamkin; Olga V Kamkina; Andrey L Shim; Andrey Bilichenko; Vadim M Mitrokhin; Viktor E Kazansky; Tatiana S Filatova; Denis V Abramochkin; Mitko I Mladenov
Journal:  Physiol Rep       Date:  2022-04
  2 in total

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