Literature DB >> 21161007

Alpha-fetoprotein specific CD4 and CD8 T cell responses in patients with hepatocellular carcinoma.

Shahriar Behboudi1, Stephen P Pereira.   

Abstract

The presence of CD8 T cell responses to tumor associated antigens have been reported in patients with different malignancies. However, there is very little information on a comparable CD8 and CD4 T cell response to a tumor antigen in liver cancer patients. Here, we re-examine the kinetic and the pattern of T helper 1 and cytotoxic T lymphocyte responses to alpha-fetoprotein (AFP), a tumor rejection antigen in hepatocellular carcinoma (HCC). Then, we discuss the possibility of using AFP-based immunotherapy in combination with necrotizing treatments in HCC patients.

Entities:  

Keywords:  Alpha-fetoprotein; Cell-mediated immunity; Hepatocellular carcinoma; Immunotherapy

Year:  2010        PMID： 21161007      PMCID： PMC2999293          DOI： 10.4254/wjh.v2.i7.256

Source DB:  PubMed          Journal:  World J Hepatol


  42 in total

1.  Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1.

Authors:  Naomi N Hunder; Herschel Wallen; Jianhong Cao; Deborah W Hendricks; John Z Reilly; Rebecca Rodmyre; Achim Jungbluth; Sacha Gnjatic; John A Thompson; Cassian Yee
Journal:  N Engl J Med       Date:  2008-06-19       Impact factor: 91.245

2.  Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer.

Authors:  Junko Matsuzaki; Sacha Gnjatic; Paulette Mhawech-Fauceglia; Amy Beck; Austin Miller; Takemasa Tsuji; Cheryl Eppolito; Feng Qian; Shashikant Lele; Protul Shrikant; Lloyd J Old; Kunle Odunsi
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-12       Impact factor: 11.205

3.  Generation of human T-cell responses to an HLA-A2.1-restricted peptide epitope derived from alpha-fetoprotein.

Authors:  L H Butterfield; A Koh; W Meng; C M Vollmer; A Ribas; V Dissette; E Lee; J A Glaspy; W H McBride; J S Economou
Journal:  Cancer Res       Date:  1999-07-01       Impact factor: 12.701

4.  Hierarchy of alpha fetoprotein (AFP)-specific T cell responses in subjects with AFP-positive hepatocellular cancer.

Authors:  Yang Liu; Sean Daley; Viktoria N Evdokimova; David D Zdobinski; Douglas M Potter; Lisa H Butterfield
Journal:  J Immunol       Date:  2006-07-01       Impact factor: 5.422

5.  Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.

Authors:  Gabriel Bricard; Hanifa Bouzourene; Olivier Martinet; Donata Rimoldi; Nermin Halkic; Michel Gillet; Pascal Chaubert; H Robson Macdonald; Pedro Romero; Jean-Charles Cerottini; Daniel E Speiser
Journal:  J Immunol       Date:  2005-02-01       Impact factor: 5.422

6.  Immunoregulation of dendritic and T cells by alpha-fetoprotein in patients with hepatocellular carcinoma.

Authors:  Marcus Ritter; Mona Y Ali; Christian F Grimm; Robert Weth; Leonhard Mohr; Wulf O Bocher; Katja Endrulat; Heiner Wedemeyer; Hubert E Blum; Michael Geissler
Journal:  J Hepatol       Date:  2004-12       Impact factor: 25.083

Review 7.  Regulatory T cells in cancer.

Authors:  Marc Beyer; Joachim L Schultze
Journal:  Blood       Date:  2006-08-01       Impact factor: 22.113

8.  Low-dose cyclophosphamide treatment impairs regulatory T cells and unmasks AFP-specific CD4+ T-cell responses in patients with advanced HCC.

Authors:  Tim F Greten; Lars A Ormandy; Annika Fikuart; Bastian Höchst; Sylvana Henschen; Monique Hörning; Michael P Manns; Firouzeh Korangy
Journal:  J Immunother       Date:  2010 Feb-Mar       Impact factor: 4.456

9.  Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection.

Authors:  Qiang Gao; Shuang-Jian Qiu; Jia Fan; Jian Zhou; Xiao-Ying Wang; Yong-Sheng Xiao; Yang Xu; Yi-Wei Li; Zhao-You Tang
Journal:  J Clin Oncol       Date:  2007-06-20       Impact factor: 44.544

10.  Spontaneous and vaccine induced AFP-specific T cell phenotypes in subjects with AFP-positive hepatocellular cancer.

Authors:  Lisa H Butterfield; Antoni Ribas; Douglas M Potter; James S Economou
Journal:  Cancer Immunol Immunother       Date:  2007-05-24       Impact factor: 6.968
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  8 in total

1.  Correlation analysis of peripheral blood T cell subgroups, immunoglobulin and prognosis of early hepatocellular carcinoma after hepatectomy.

Authors:  Yi-Qun Che; Lin Feng; Wei-Qi Rong; Di Shen; Qian Wang; Lin Yang; Jun Qi; Chang-Zhi Huang
Journal:  Int J Clin Exp Med       Date:  2014-11-15

Review 2.  Rationally combining anti-VEGF therapy with checkpoint inhibitors in hepatocellular carcinoma.

Authors:  Tai Hato; Andrew X Zhu; Dan G Duda
Journal:  Immunotherapy       Date:  2016-02-11       Impact factor: 4.196

3.  Tumor-derived α-fetoprotein impairs the differentiation and T cell stimulatory activity of human dendritic cells.

Authors:  Angela D Pardee; Jian Shi; Lisa H Butterfield
Journal:  J Immunol       Date:  2014-10-29       Impact factor: 5.422

Review 4.  Cellular immune suppressor mechanisms in patients with hepatocellular carcinoma.

Authors:  Fei Zhao; Firouzeh Korangy; Tim F Greten
Journal:  Dig Dis       Date:  2012-10-24       Impact factor: 2.404

5.  Impaired function of CD4+ T follicular helper (Tfh) cells associated with hepatocellular carcinoma progression.

Authors:  Yiqiong Jia; Zhen Zeng; Yuanyuan Li; Zhiwei Li; Lei Jin; Zheng Zhang; Lifeng Wang; Fu-Sheng Wang
Journal:  PLoS One       Date:  2015-02-17       Impact factor: 3.240

6.  Route of antigen delivery impacts the immunostimulatory activity of dendritic cell-based vaccines for hepatocellular carcinoma.

Authors:  Angela D Pardee; Hiroshi Yano; Aliyah M Weinstein; Aaron A K Ponce; Alexander D Ethridge; Daniel P Normolle; Lazar Vujanovic; Gerald J Mizejewski; Simon C Watkins; Lisa H Butterfield
Journal:  J Immunother Cancer       Date:  2015-07-21       Impact factor: 13.751

7.  Alarmin augments the antitumor immunity of lentiviral vaccine in ectopic, orthotopic and autochthonous hepatocellular carcinoma mice.

Authors:  Zhili Liu; Zhen Lu; Renwei Jing; Bingfeng Zuo; Xianjun Gao; Gang Han; Han Qi; Li Wu; Yunde Liu; Haifang Yin
Journal:  Theranostics       Date:  2019-05-31       Impact factor: 11.556

Review 8.  Molecular mechanisms of circular RNAs, transforming growth factor-β, and long noncoding RNAs in hepatocellular carcinoma.

Authors:  Wenkang Shang; Gabriel Komla Adzika; Yujie Li; Qike Huang; Ningding Ding; Bianca Chinembiri; Mohammad Sajjad Ibn Rashid; Jeremiah Ong'achwa Machuki
Journal:  Cancer Med       Date:  2019-09-15       Impact factor: 4.452
  8 in total

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