Literature DB >> 21160973

Can proteomics lead to the discovery of real biomarkers for HCC?

Yasuhiro Kuramitsu1.   

Abstract

The development of proteomics technologies has lead to a great deal of effort being focused on the identification of biomarkers for cancers. Although many papers have reported candidate biomarkers for hepatocellular carcinomas (HCCs) in particular, so far none of these candidate biomarkers have been used either for diagnosis or therapy intreating patients. The question remains: Can proteomics identify real biomarkers for HCCs?

Entities:  

Keywords:  Biomarker; Hepatocellular carcinoma; Mass spectrometry; Proteomics; Two-dimensional polyacrylamide gel electrophoresis

Year:  2010        PMID: 21160973      PMCID: PMC2999271          DOI: 10.4254/wjh.v2.i2.55

Source DB:  PubMed          Journal:  World J Hepatol


  24 in total

Review 1.  Proteomics: a new approach to the study of disease.

Authors:  G Chambers; L Lawrie; P Cash; G I Murray
Journal:  J Pathol       Date:  2000-11       Impact factor: 7.996

2.  A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry.

Authors:  Ruyi Xue; Zhenxin Lin; Chunhui Deng; Ling Dong; Taotao Liu; Jiyao Wang; Xizhong Shen
Journal:  Rapid Commun Mass Spectrom       Date:  2008-10       Impact factor: 2.419

3.  Overexpression of alpha enolase in hepatitis C virus-related hepatocellular carcinoma: association with tumor progression as determined by proteomic analysis.

Authors:  Motonari Takashima; Yasuhiro Kuramitsu; Yuichiro Yokoyama; Norio Iizuka; Masanori Fujimoto; Takashi Nishisaka; Kiwamu Okita; Masaaki Oka; Kazuyuki Nakamura
Journal:  Proteomics       Date:  2005-04       Impact factor: 3.984

Review 4.  Cancer proteomics: from identification of novel markers to creation of artifical learning models for tumor classification.

Authors:  A A Alaiya; B Franzén; G Auer; S Linder
Journal:  Electrophoresis       Date:  2000-04       Impact factor: 3.535

Review 5.  Biomedical applications of two-dimensional electrophoresis using immobilized pH gradients: current status.

Authors:  S M Hanash
Journal:  Electrophoresis       Date:  2000-04       Impact factor: 3.535

6.  Proteomic analysis and molecular characterization of tissue ferritin light chain in hepatocellular carcinoma.

Authors:  Kang-Sik Park; Hoguen Kim; Nam-Gyun Kim; Sang Yun Cho; Kun-Ho Choi; Je Kyung Seong; Young-Ki Paik
Journal:  Hepatology       Date:  2002-06       Impact factor: 17.425

Review 7.  Comparative analysis of the liver and plasma proteomes as a novel and powerful strategy for hepatocellular carcinoma biomarker discovery.

Authors:  Laura Beretta
Journal:  Cancer Lett       Date:  2009-02-15       Impact factor: 8.679

Review 8.  Systematic -omics analysis of HBV-associated liver diseases.

Authors:  Wei Sun; Fan Zhong; Lianteng Zhi; Gangqiao Zhou; Fuchu He
Journal:  Cancer Lett       Date:  2009-01-13       Impact factor: 8.679

9.  Metabolomic profiling of human urine in hepatocellular carcinoma patients using gas chromatography/mass spectrometry.

Authors:  Hao Wu; Ruyi Xue; Ling Dong; Taotao Liu; Chunhui Deng; Huazong Zeng; Xizhong Shen
Journal:  Anal Chim Acta       Date:  2009-06-21       Impact factor: 6.558

10.  Proteomic expression signature distinguishes cancerous and nonmalignant tissues in hepatocellular carcinoma.

Authors:  Nikki P Lee; Lei Chen; Marie C Lin; Felice H Tsang; Chun Yeung; Ronnie T Poon; Jirun Peng; Xisheng Leng; Laura Beretta; Stella Sun; Philip J Day; John M Luk
Journal:  J Proteome Res       Date:  2009-03       Impact factor: 4.466

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