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Literature DB >> 21160770

Potential of casein kinase I in digestive cancer screening.

Abstract

Casein kinase I is a group of ubiquitous Serine/Threonine kinases that have been implicated in both normal cellular functions and several pathological conditions including Alzheimer's disease and cancer. Recent findings in colon and pancreatic cancer have brought tremendous attention to these molecules as potential therapeutic targets in treatment of digestive cancers. In this review, we summarize up to date what is known about this family of kinases and their involvement in carcinogenesis and other pathological conditions. Our emphasis is on their implications in digestive cancers and their potential for cancer screening and therapy.

Entities: Disease

Keywords: Biomarkers; Casein kinase I; Colon cancer; Gastric cancer; Pancreatic cancer

Year: 2009 PMID： 21160770 PMCID： PMC2999098 DOI： 10.4251/wjgo.v1.i1.26

Source DB: PubMed Journal: World J Gastrointest Oncol

64 in total

1. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

Authors: J Brognard; A S Clark; Y Ni; P A Dennis
Journal: Cancer Res Date: 2001-05-15 Impact factor: 12.701

2. IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects.

Authors: L Behrend; D M Milne; M Stöter; W Deppert; L E Campbell; D W Meek; U Knippschild
Journal: Oncogene Date: 2000-11-09 Impact factor: 9.867

3. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.

Authors: Sharon Amit; Ada Hatzubai; Yaara Birman; Jens S Andersen; Etti Ben-Shushan; Matthias Mann; Yinon Ben-Neriah; Irit Alkalay
Journal: Genes Dev Date: 2002-05-01 Impact factor: 11.361

4. Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.

Authors: Ying Xu; Quasar S Padiath; Robert E Shapiro; Christopher R Jones; Susan C Wu; Noriko Saigoh; Kazumasa Saigoh; Louis J Ptácek; Ying-Hui Fu
Journal: Nature Date: 2005-03-31 Impact factor: 49.962

Review 5. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways.

Authors: Lionel Larue; Alfonso Bellacosa
Journal: Oncogene Date: 2005-11-14 Impact factor: 9.867

6. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo.

Authors: C Brockschmidt; H Hirner; N Huber; T Eismann; A Hillenbrand; G Giamas; B Radunsky; O Ammerpohl; B Bohm; D Henne-Bruns; H Kalthoff; F Leithäuser; A Trauzold; U Knippschild
Journal: Gut Date: 2008-01-18 Impact factor: 23.059

7. A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders.

Authors: Atsuko Takano; Makoto Uchiyama; Naofumi Kajimura; Kazuo Mishima; Yuichi Inoue; Yuichi Kamei; Tsuyoshi Kitajima; Kayo Shibui; Masaaki Katoh; Tsuyoshi Watanabe; Yuki Hashimotodani; Toru Nakajima; Yuji Ozeki; Toru Hori; Naoto Yamada; Ryoichi Toyoshima; Norio Ozaki; Masako Okawa; Katsuya Nagai; Kiyohisa Takahashi; Yasushi Isojima; Toshio Yamauchi; Takashi Ebisawa
Journal: Neuropsychopharmacology Date: 2004-10 Impact factor: 7.853

8. A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins.

Authors: Oriano Marin; Victor H Bustos; Luca Cesaro; Flavio Meggio; Mario A Pagano; Marcelo Antonelli; Catherine C Allende; Lorenzo A Pinna; Jorge E Allende
Journal: Proc Natl Acad Sci U S A Date: 2003-08-18 Impact factor: 11.205

Potential of casein kinase I in digestive cancer screening.

1. Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

2. IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects.

3. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.

4. Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome.

Review 5. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways.

6. Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo.

7. A missense variation in human casein kinase I epsilon gene that induces functional alteration and shows an inverse association with circadian rhythm sleep disorders.

8. A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins.

9. Casein Kinase I epsilon positively regulates the Akt pathway in breast cancer cell lines.

10. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest.

Review 1. Circadian clock circuitry in colorectal cancer.

2. Expression of PER, CRY, and TIM genes for the pathological features of colorectal cancer patients.

3. CK1α overexpression correlates with poor survival in colorectal cancer.

4. A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε.

5. Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients.

6. High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer.