| Literature DB >> 21160279 |
Zhixun Dou1, Ji-An Pan, Richard Z Lin, Wei-Xing Zong.
Abstract
Autophagy is critically controlled by phosphatidylinositol 3-kinases (PtdIns3Ks). The common understanding for mammalian autophagy is that class I PtdIns3Ks inhibit autophagy by activating the Akt-TOR kinase cascade, whereas the class III PtdIns3K (Vps34) promotes autophagy by generating the phospholipid PtdIns(3)P. However, direct genetic evidence for a role of class I PtdIns3Ks in autophagy has been lacking. Using mice with a conditional deletion of the class I PtdIns3K catalytic subunit isoform p110α or p110β, we revealed an unexpected function of p110β as a positive regulator of autophagy.Entities:
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Year: 2011 PMID： 21160279 PMCID： PMC3359470 DOI： 10.4161/auto.7.2.14346
Source DB: PubMed Journal: Autophagy ISSN： 1554-8627 Impact factor: 16.016