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Literature DB >> 2116012

Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei.

N Aronin¹, S M Sagar, F R Sharp, W J Schwartz.

Abstract

Mammalian circadian rhythmicity is endogenously generated by a pacemaker in the suprachiasmatic nuclei and precisely entrained to the 24-hr day/night cycle by periodic environmental light cues. We show that light alters the immunoreactive levels of a transcriptional regulatory protein, Fos, in the suprachiasmatic nuclei of albino rats. Photic regulation of Fos immunoreactivity does not occur in other retino-recipient brain areas except for the intergeniculate leaflet, which appears to be involved in mediating some of the complex effects of light on expressed circadian rhythms. Our results point to a promising new functional marker for the cellular effects of light and suggest that the expression of Fos or a related nuclear protein may be part of the mechanism for photic entrainment of the circadian clock to environmental light/dark cycles.

Entities: Gene Species

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Year: 1990 PMID： 2116012 PMCID： PMC54449 DOI： 10.1073/pnas.87.15.5959

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

56 in total

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Journal: Brain Res Date: 1987-05-05 Impact factor: 3.252

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Journal: Brain Res Date: 1987-02-17 Impact factor: 3.252

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Journal: J Biol Rhythms Date: 1987 Impact factor: 3.182

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44 in total

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Journal: Neurochem Res Date: 2000-01 Impact factor: 3.996

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Journal: J Neurosci Date: 2003-02-15 Impact factor: 6.167

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Authors: O Dkhissi-Benyahya; B Sicard; H M Cooper
Journal: J Neurosci Date: 2000-10-15 Impact factor: 6.167

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Journal: Neurochem Res Date: 1997-05 Impact factor: 3.996

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Journal: Proc Natl Acad Sci U S A Date: 1992-11-15 Impact factor: 11.205

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Journal: Proc Natl Acad Sci U S A Date: 1992-01-01 Impact factor: 11.205

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Authors: S Sekaran; D Lupi; S L Jones; C J Sheely; S Hattar; K-W Yau; R J Lucas; R G Foster; M W Hankins
Journal: Curr Biol Date: 2005-06-21 Impact factor: 10.834