Literature DB >> 21160113

Absorbed fractions for electrons in ellipsoidal volumes.

E Amato1, D Lizio, S Baldari.   

Abstract

We applied a Monte Carlo simulation in Geant4 in order to calculate the absorbed fractions for monoenergetic electrons in the energy interval between 10 keV and 2 MeV, uniformly distributed in ellipsoids made from soft tissue. For each volume, we simulated a spherical shape, four oblate and four prolate ellipsoids, and one scalene shape. For each energy and for every geometrical configuration, an analytical relationship between the absorbed fraction and a 'generalized radius' was found, and the dependence of the fit parameters from electron energy is discussed and fitted by proper parametric functions. With the proposed formulation, the absorbed fraction for electrons in the 10-2000 keV energy range can be calculated for all volumes and for every ellipsoidal shape of practical interest. This method can be directly applied to evaluation of the absorbed fraction from the radionuclide emission of monoenergetic electrons, such as Auger or conversion electrons. The average deposited energy per disintegration in the case of extended beta spectra can be evaluated through integration. Two examples of application to a pure beta emitter such as (90)Y and to (131)I, whose emission include monoenergetic and beta electrons plus gamma photons, are presented. This approach represent a generalization of our previous studies, allowing a comprehensive treatment of absorbed fractions from electron and photon sources uniformly distributed in ellipsoidal volumes of any ellipticity and volume, in the whole range of practical interest for internal dosimetry in nuclear medicine applications, as well as in radiological protection estimations of doses from an internal contamination.

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Year:  2010        PMID: 21160113     DOI: 10.1088/0031-9155/56/2/005

Source DB:  PubMed          Journal:  Phys Med Biol        ISSN: 0031-9155            Impact factor:   3.609


  7 in total

1.  Monte Carlo single-cell dosimetry using Geant4-DNA: the effects of cell nucleus displacement and rotation on cellular S values.

Authors:  Ramak Salim; Payvand Taherparvar
Journal:  Radiat Environ Biophys       Date:  2019-03-29       Impact factor: 1.925

2.  Investigation of 90Y-avidin for prostate cancer brachytherapy: a dosimetric model for a phase I-II clinical study.

Authors:  Francesca Botta; Marta Cremonesi; Mahila E Ferrari; Ernesto Amato; Francesco Guerriero; Andrea Vavassori; Anna Sarnelli; Stefano Severi; Guido Pedroli; Giovanni Paganelli
Journal:  Eur J Nucl Med Mol Imaging       Date:  2013-05-03       Impact factor: 9.236

3.  An analytical model for calculating internal dose conversion coefficients for non-human biota.

Authors:  Ernesto Amato; Antonio Italiano
Journal:  Radiat Environ Biophys       Date:  2014-03-26       Impact factor: 1.925

4.  VIDA: a voxel-based dosimetry method for targeted radionuclide therapy using Geant4.

Authors:  Susan D Kost; Yuni K Dewaraja; Richard G Abramson; Michael G Stabin
Journal:  Cancer Biother Radiopharm       Date:  2015-01-16       Impact factor: 3.099

5.  Internal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice.

Authors:  Francesco Cicone; Silvano Gnesin; Thibaut Denoël; Thierry Stora; Nicholas P van der Meulen; Cristina Müller; Christiaan Vermeulen; Martina Benešová; Ulli Köster; Karl Johnston; Ernesto Amato; Lucrezia Auditore; George Coukos; Michael Stabin; Niklaus Schaefer; David Viertl; John O Prior
Journal:  EJNMMI Res       Date:  2019-06-11       Impact factor: 3.138

6.  Estimation of absorbed dose to the kidneys in patients after treatment with 177Lu-octreotate: comparison between methods based on planar scintigraphy.

Authors:  Maria Larsson; Peter Bernhardt; Johanna B Svensson; Bo Wängberg; Håkan Ahlman; Eva Forssell-Aronsson
Journal:  EJNMMI Res       Date:  2012-09-24       Impact factor: 3.138

7.  Effect of Beta Particles Spectrum on Absorbed Fraction in Internal Radiotherapy.

Authors:  Marjan Hashempour; Mahdi Ghorbani; Ernesto Amato; Courtney Knaup
Journal:  Asia Ocean J Nucl Med Biol       Date:  2019
  7 in total

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