Literature DB >> 21160075

Personalized prostate cancer screening: improving PSA tests with genomic information.

John S Witte1.   

Abstract

The use of a prostate-specific antigen (PSA) test to screen for prostate cancer is controversial because of its modest predictive value and the potential overdiagnosis and over-treatment of the disease. A research article in this issue of Science Translational Medicine describes single-nucleotide polymorphisms (SNPs) in or near six genes that are independently associated with serum PSA concentrations and that help to explain interindividual PSA variation. Three of these SNPs are also associated with prostate biopsy outcomes. These findings are an important step toward incorporating genetic markers into PSA screening, with the ultimate goal of devising personalized PSA tests for use in the clinic.

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Year:  2010        PMID： 21160075     DOI： 10.1126/scitranslmed.3001861

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  11 in total

1.  Historical prostate cancer screening and treatment outcomes from a single institution.

Authors:  Deanna S Cross; Mark Ritter; Douglas J Reding
Journal:  Clin Med Res       Date:  2012-04-25

2.  Diverse functional networks of Tbx3 in development and disease.

Authors:  Andrew J Washkowitz; Svetlana Gavrilov; Salma Begum; Virginia E Papaioannou
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2012-02-14

Review 3.  Multigene panels in prostate cancer risk assessment: a systematic review.

Authors:  Julian Little; Brenda Wilson; Ron Carter; Kate Walker; Pasqualina Santaguida; Eva Tomiak; Joseph Beyene; Muhammad Usman Ali; Parminder Raina
Journal:  Genet Med       Date:  2015-10-01       Impact factor: 8.822

4.  A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data.

Authors:  Minh-Phuong Huynh-Le; Chun Chieh Fan; Roshan Karunamuni; Eleanor I Walsh; Emma L Turner; J Athene Lane; Richard M Martin; David E Neal; Jenny L Donovan; Freddie C Hamdy; J Kellogg Parsons; Rosalind A Eeles; Douglas F Easton; Zsofia Kote-Jarai; Ali Amin Al Olama; Sara Benlloch Garcia; Kenneth Muir; Henrik Grönberg; Fredrik Wiklund; Markus Aly; Johanna Schleutker; Csilla Sipeky; Teuvo Lj Tammela; Børge Grønne Nordestgaard; Timothy J Key; Ruth C Travis; Paul D P Pharoah; Nora Pashayan; Kay-Tee Khaw; Stephen N Thibodeau; Shannon K McDonnell; Daniel J Schaid; Christiane Maier; Walther Vogel; Manuel Luedeke; Kathleen Herkommer; Adam S Kibel; Cezary Cybulski; Dominika Wokolorczyk; Wojciech Kluzniak; Lisa A Cannon-Albright; Hermann Brenner; Ben Schöttker; Bernd Holleczek; Jong Y Park; Thomas A Sellers; Hui-Yi Lin; Chavdar Kroumov Slavov; Radka P Kaneva; Vanio I Mitev; Jyotsna Batra; Judith A Clements; Amanda B Spurdle; Manuel R Teixeira; Paula Paulo; Sofia Maia; Hardev Pandha; Agnieszka Michael; Ian G Mills; Ole A Andreassen; Anders M Dale; Tyler M Seibert
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2020-06-24       Impact factor: 4.254

5.  Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis.

Authors:  Wensheng Zhang; Yan Dong; Oliver Sartor; Kun Zhang
Journal:  Cancer Prev Res (Phila)       Date:  2021-04-17

6.  Incorporating Known Genetic Variants Does Not Improve the Accuracy of PSA Testing to Identify High Risk Prostate Cancer on Biopsy.

Authors:  Rebecca Gilbert; Richard M Martin; David M Evans; Kate Tilling; George Davey Smith; John P Kemp; J Athene Lane; Freddie C Hamdy; David E Neal; Jenny L Donovan; Chris Metcalfe
Journal:  PLoS One       Date:  2015-10-02       Impact factor: 3.240

7.  Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.

Authors:  Thomas J Hoffmann; Michael N Passarelli; Rebecca E Graff; Nima C Emami; Lori C Sakoda; Eric Jorgenson; Laurel A Habel; Jun Shan; Dilrini K Ranatunga; Charles P Quesenberry; Chun R Chao; Nirupa R Ghai; David Aaronson; Joseph Presti; Tobias Nordström; Zhaoming Wang; Sonja I Berndt; Stephen J Chanock; Jonathan D Mosley; Robert J Klein; Mridu Middha; Hans Lilja; Olle Melander; Mark N Kvale; Pui-Yan Kwok; Catherine Schaefer; Neil Risch; Stephen K Van Den Eeden; John S Witte
Journal:  Nat Commun       Date:  2017-01-31       Impact factor: 14.919

8.  Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.

Authors:  Tyler M Seibert; Chun Chieh Fan; Yunpeng Wang; Verena Zuber; Roshan Karunamuni; J Kellogg Parsons; Rosalind A Eeles; Douglas F Easton; ZSofia Kote-Jarai; Ali Amin Al Olama; Sara Benlloch Garcia; Kenneth Muir; Henrik Grönberg; Fredrik Wiklund; Markus Aly; Johanna Schleutker; Csilla Sipeky; Teuvo Lj Tammela; Børge G Nordestgaard; Sune F Nielsen; Maren Weischer; Rasmus Bisbjerg; M Andreas Røder; Peter Iversen; Tim J Key; Ruth C Travis; David E Neal; Jenny L Donovan; Freddie C Hamdy; Paul Pharoah; Nora Pashayan; Kay-Tee Khaw; Christiane Maier; Walther Vogel; Manuel Luedeke; Kathleen Herkommer; Adam S Kibel; Cezary Cybulski; Dominika Wokolorczyk; Wojciech Kluzniak; Lisa Cannon-Albright; Hermann Brenner; Katarina Cuk; Kai-Uwe Saum; Jong Y Park; Thomas A Sellers; Chavdar Slavov; Radka Kaneva; Vanio Mitev; Jyotsna Batra; Judith A Clements; Amanda Spurdle; Manuel R Teixeira; Paula Paulo; Sofia Maia; Hardev Pandha; Agnieszka Michael; Andrzej Kierzek; David S Karow; Ian G Mills; Ole A Andreassen; Anders M Dale
Journal:  BMJ       Date:  2018-01-10

9.  Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.

Authors:  Minh-Phuong Huynh-Le; Chun Chieh Fan; Roshan Karunamuni; Wesley K Thompson; Maria Elena Martinez; Rosalind A Eeles; Zsofia Kote-Jarai; Kenneth Muir; Johanna Schleutker; Nora Pashayan; Jyotsna Batra; Henrik Grönberg; David E Neal; Jenny L Donovan; Freddie C Hamdy; Richard M Martin; Sune F Nielsen; Børge G Nordestgaard; Fredrik Wiklund; Catherine M Tangen; Graham G Giles; Alicja Wolk; Demetrius Albanes; Ruth C Travis; William J Blot; Wei Zheng; Maureen Sanderson; Janet L Stanford; Lorelei A Mucci; Catharine M L West; Adam S Kibel; Olivier Cussenot; Sonja I Berndt; Stella Koutros; Karina Dalsgaard Sørensen; Cezary Cybulski; Eli Marie Grindedal; Florence Menegaux; Kay-Tee Khaw; Jong Y Park; Sue A Ingles; Christiane Maier; Robert J Hamilton; Stephen N Thibodeau; Barry S Rosenstein; Yong-Jie Lu; Stephen Watya; Ana Vega; Manolis Kogevinas; Kathryn L Penney; Chad Huff; Manuel R Teixeira; Luc Multigner; Robin J Leach; Lisa Cannon-Albright; Hermann Brenner; Esther M John; Radka Kaneva; Christopher J Logothetis; Susan L Neuhausen; Kim De Ruyck; Hardev Pandha; Azad Razack; Lisa F Newcomb; Jay H Fowke; Marija Gamulin; Nawaid Usmani; Frank Claessens; Manuela Gago-Dominguez; Paul A Townsend; William S Bush; Monique J Roobol; Marie-Élise Parent; Jennifer J Hu; Ian G Mills; Ole A Andreassen; Anders M Dale; Tyler M Seibert
Journal:  Nat Commun       Date:  2021-02-23       Impact factor: 14.919

10.  National Cancer Institute Prostate Cancer Genetics Workshop.

Authors:  William J Catalona; Joan E Bailey-Wilson; Nicola J Camp; Stephen J Chanock; Kathleen A Cooney; Douglas F Easton; Rosalind A Eeles; Liesel M FitzGerald; Matthew L Freedman; Julius Gudmundsson; Rick A Kittles; Elliott H Margulies; Barry B McGuire; Elaine A Ostrander; Timothy R Rebbeck; Janet L Stanford; Stephen N Thibodeau; John S Witte; William B Isaacs
Journal:  Cancer Res       Date:  2011-05-10       Impact factor: 12.701
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