Literature DB >> 2115497

Antibodies to a phospholipase A2 from Vipera russelli selectively neutralize venom neurotoxicity.

S Kasturi1, L M Rudrammaji, T V Gowda.   

Abstract

Polyclonal antibodies to a purified neurotoxic phospholipase A2 (PLA2), VRV PL-VIIIa, from Vipera russelli venom were raised in rabbits. Anti-PL-VIIIa-Ig (gamma-globulin fraction of rabbit antiserum injected with VRV PL-VIIIa) selectively neutralized the neurotoxicity of VRV PL-VIIIa, VRV PL-V, VRV PL-VI (neurotoxic PLA2 of V. russelli venom) and whole V. russelli venom without affecting their PLA2 activity, which clearly demonstrates that the catalytic site and the neurotoxic site (the site through which the PLA2 binds to the nervous system) are distinct on a PLA2 molecule. Anti-PL-VIIIa Ig did not have any effect on the oedema-inducing activity and indirect haemolytic activity of VRV PL-VIIIa, VRV PL-V and VRV PL-VI, which are attributed to the PLA2 activity of the peptide, but inhibited their anti-coagulant potency.

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Year:  1990        PMID： 2115497      PMCID： PMC1384189     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  10 in total

Review 1.  A model to explain the pharmacological effects of snake venom phospholipases A2.

Authors:  R M Kini; H J Evans
Journal:  Toxicon       Date:  1989       Impact factor: 3.033

2.  Non-enzymatic inhibitors of coagulation and platelet aggregation from Naja nigricollis venom are cardiotoxins.

Authors:  R M Kini; N C Haar; H J Evans
Journal:  Biochem Biophys Res Commun       Date:  1988-02-15       Impact factor: 3.575

3.  Dissociation of catalytic activity and neurotoxicity of a basic phospholipase A2 from Russell's viper (Vipera russelli) venom.

Authors:  G P Jayanthi; S Kasturi; T V Gowda
Journal:  Toxicon       Date:  1989       Impact factor: 3.033

4.  Purification and characterization of a major phospholipase A2 from Russell's viper (Vipera russelli) venom.

Authors:  S Kasturi; T V Gowda
Journal:  Toxicon       Date:  1989       Impact factor: 3.033

5.  Analytical differential centrifugation: an analysis of the sedimentation properties of synaptosomes, mitochondria and lysosomes from rat brain homogenates.

Authors:  C Cotman; D H Brown; B W Harrell; N G Anderson
Journal:  Arch Biochem Biophys       Date:  1970-02       Impact factor: 4.013

6.  Characterization of three edema-inducing phospholipase A2 enzymes from habu (Trimeresurus flavoviridis) venom and their interaction with the alkaloid aristolochic acid.

Authors:  B S Vishwanath; R M Kini; T V Gowda
Journal:  Toxicon       Date:  1987       Impact factor: 3.033

7.  A new method for quantitating hemorrhage induced by rattlesnake venoms: ability of polyvalent antivenom to neutralize hemorrhagic activity.

Authors:  C L Ownby; T R Colberg; G V Odell
Journal:  Toxicon       Date:  1984       Impact factor: 3.033

Review 8.  Structure-function relationships of phospholipases. II: Charge density distribution and the myotoxicity of presynaptically neurotoxic phospholipases.

Authors:  R M Kini; S Iwanaga
Journal:  Toxicon       Date:  1986       Impact factor: 3.033

9.  Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid.

Authors:  B S Vishwanath; A A Fawzy; R C Franson
Journal:  Inflammation       Date:  1988-12       Impact factor: 4.092

10.  Structure-function relationships of phospholipases. I: Prediction of presynaptic neurotoxicity.

Authors:  R M Kini; S Iwanaga
Journal:  Toxicon       Date:  1986       Impact factor: 3.033
  10 in total
  3 in total

1.  Purification and characterization of a potent hemolytic toxin with phospholipase A2 activity from the venom of Indian Russell's viper.

Authors:  Amit K Chakraborty; Robert H Hall; Asoke C Ghose
Journal:  Mol Cell Biochem       Date:  2002-08       Impact factor: 3.396

2.  Characterization of a human coagulation factor Xa-binding site on Viperidae snake venom phospholipases A2 by affinity binding studies and molecular bioinformatics.

Authors:  Grazyna Faure; Veerabasappa T Gowda; Rachid C Maroun
Journal:  BMC Struct Biol       Date:  2007-12-06

3.  Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2.

Authors:  Catherine A Vulfius; Igor E Kasheverov; Vladislav G Starkov; Alexey V Osipov; Tatyana V Andreeva; Sergey Yu Filkin; Elena V Gorbacheva; Maxim E Astashev; Victor I Tsetlin; Yuri N Utkin
Journal:  PLoS One       Date:  2014-12-18       Impact factor: 3.240
  3 in total

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