STUDY OBJECTIVE: This study was a literature review designed to assess the rates of psychotropic "polypharmacy" in the pediatric population. Psychotropic polypharmacy was defined as the practice of prescribing two or more medications (e.g. concomitant psychotropic medications) for one or more diagnosed psychiatric conditions and/or behavioral symptoms. METHODS: A literature review of relevant articles pertaining to polypharmacy was completed using the Pub Med database from 1994 through April 2004 for pediatric populations under 18 years old. RESULTS: Studies were reviewed from various pediatric settings. While the extent of polypharmacy varied from the different populations, all the studies comparing these rates across time showed an increase in this practice. The use of stimulants with another psychotropic medication was the most frequent combination. CONCLUSIONS: There is limited information about the actual rates of psychotropic polypharmacy in the pediatric population. However, the data that are available demonstrate that this practice is on the rise. This is of specific concern due to the increase of adverse events with polypharmacy. The implications of polypharmacy, including efficacy and side effects, are generally unknown and may vary by specific combination. Therefore, these prescribing practices should be conducted with caution, and systematic research is needed.
STUDY OBJECTIVE: This study was a literature review designed to assess the rates of psychotropic "polypharmacy" in the pediatric population. Psychotropic polypharmacy was defined as the practice of prescribing two or more medications (e.g. concomitant psychotropic medications) for one or more diagnosed psychiatric conditions and/or behavioral symptoms. METHODS: A literature review of relevant articles pertaining to polypharmacy was completed using the Pub Med database from 1994 through April 2004 for pediatric populations under 18 years old. RESULTS: Studies were reviewed from various pediatric settings. While the extent of polypharmacy varied from the different populations, all the studies comparing these rates across time showed an increase in this practice. The use of stimulants with another psychotropic medication was the most frequent combination. CONCLUSIONS: There is limited information about the actual rates of psychotropic polypharmacy in the pediatric population. However, the data that are available demonstrate that this practice is on the rise. This is of specific concern due to the increase of adverse events with polypharmacy. The implications of polypharmacy, including efficacy and side effects, are generally unknown and may vary by specific combination. Therefore, these prescribing practices should be conducted with caution, and systematic research is needed.
Authors: Julie Magno Zito; Daniel J Safer; Susan DosReis; James F Gardner; Laurence Magder; Karen Soeken; Myde Boles; Frances Lynch; Mark A Riddle Journal: Arch Pediatr Adolesc Med Date: 2003-01
Authors: Marsha D Rappley; Ihuoma U Eneli; Patricia B Mullan; Francisco J Alvarez; Jenny Wang; Zhehui Luo; Joseph C Gardiner Journal: J Dev Behav Pediatr Date: 2002-02 Impact factor: 2.225
Authors: Benedetto Vitiello; Mark A Riddle; Laurence L Greenhill; John S March; Jerome Levine; Russell J Schachar; Howard Abikoff; Julie M Zito; James T McCracken; John T Walkup; Robert L Findling; James Robinson; Thomas B Cooper; Mark Davies; Elena Varipatis; Michael J Labellarte; Lawrence Scahill; Lisa Capasso Journal: J Am Acad Child Adolesc Psychiatry Date: 2003-06 Impact factor: 8.829