Topiramate for hyperphagia associated with a third ventricle mass.

Hypothalamic control of eating functions can be affected by different physiopathologic events or injuries. A case report of an individual with a mass in the third ventricle is presented. Neuropsychiatric manifestations included hyperphagia, agitation, and cognitive impairment. Pharmacological intervention with topiramate (Topomax(®), Ortho-McNeil Pharmaceuticals) helped the hyperphagia and agitation better than other agents tried. Possible mechanisms of action of this agent are discussed.