Literature DB >> 21151843

Facile Route to Tetrasubstituted Pyrazoles Utilizing Ceric Ammonium Nitrate.

James J Devery1, Pramod K Mohanta, Brian M Casey, Robert A Flowers.   

Abstract

A convenient approach for the synthesis of tetrasubstituted pyrazoles is described. The method involves the treatment of 1,3-diketones and allyltrimethylsilane with CAN followed by cerium-catalyzed addition of substituted hydrazines to construct pyrazoles in good yields.

Entities:  

Year:  2009        PMID： 21151843      PMCID： PMC2998890          DOI： 10.1055/s-0029-1217163

Source DB:  PubMed          Journal:  Synlett        ISSN： 0936-5214            Impact factor:   2.454


  16 in total

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2.  Optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type I receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type I inhibitor as antitumor agent.

Authors:  Hong-Yu Li; William T McMillen; Charles R Heap; Denis J McCann; Lei Yan; Robert M Campbell; Sreenivasa R Mundla; Chi-Hsin R King; Elizabeth A Dierks; Bryan D Anderson; Karen S Britt; Karen L Huss; Matthew D Voss; Yan Wang; David K Clawson; Jonathan M Yingling; J Scott Sawyer
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3.  Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.

Authors:  Hongwu Wang; Ruth A Duffy; George C Boykow; Samuel Chackalamannil; Vincent S Madison
Journal:  J Med Chem       Date:  2008-03-26       Impact factor: 7.446

4.  Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.

Authors:  S R Stauffer; C J Coletta; R Tedesco; G Nishiguchi; K Carlson; J Sun; B S Katzenellenbogen; J A Katzenellenbogen
Journal:  J Med Chem       Date:  2000-12-28       Impact factor: 7.446

5.  The effect of 1,3-diaryl-[1H]-pyrazole-4-acetamides on glucose utilization in ob/ob mice.

Authors:  G R Bebernitz; G Argentieri; B Battle; C Brennan; B Balkan; B F Burkey; M Eckhardt; J Gao; P Kapa; R J Strohschein; H F Schuster; M Wilson; D D Xu
Journal:  J Med Chem       Date:  2001-08-02       Impact factor: 7.446

6.  Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives.

Authors:  M J Genin; C Biles; B J Keiser; S M Poppe; S M Swaney; W G Tarpley; Y Yagi; D L Romero
Journal:  J Med Chem       Date:  2000-03-09       Impact factor: 7.446

7.  Mechanistic investigation of substrate oxidation by Ce(IV) reagents in acetonitrile.

Authors:  Yang Zhang; Robert A Flowers
Journal:  J Org Chem       Date:  2003-05-30       Impact factor: 4.354

8.  Density functional theory calculation of 13C NMR shifts of diazaphenanthrene alkaloids: reinvestigation of the structure of samoquasine A.

Authors:  Cody Timmons; Peter Wipf
Journal:  J Org Chem       Date:  2008-10-17       Impact factor: 4.354

9.  Solvent-dependent chemoselectivities in Ce(IV)-mediated oxidative coupling reactions.

Authors:  Yang Zhang; Andrew J Raines; Robert A Flowers
Journal:  Org Lett       Date:  2003-06-26       Impact factor: 6.005

10.  Mechanistic studies of Ce(IV)-mediated oxidation of beta-dicarbonyls: solvent-dependent behavior of radical cation intermediates.

Authors:  Jingliang Jiao; Yang Zhang; James J Devery; Luna Xu; Jennifer Deng; Robert A Flowers
Journal:  J Org Chem       Date:  2007-06-28       Impact factor: 4.354
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  2 in total

1.  One Pot Spiropyrazoline Synthesis via Intramolecular Cyclization/Methylation.

Authors:  Sureshbabu Dadiboyena; Ashton T Hamme
Journal:  Tetrahedron Lett       Date:  2011-05-18       Impact factor: 2.415

2.  Oxidative carbon-carbon bond formation via allyldimethylsilyl enol ethers.

Authors:  Leah C Konkol; Brian T Jones; Regan J Thomson
Journal:  Org Lett       Date:  2009-12-03       Impact factor: 6.005
  2 in total

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