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Literature DB >> 211513

Ontogeny of synaptic phosphoproteins in brain.

Abstract

The ontogeny of two endogenous substrates for cyclic AMP-dependent protein kinase (ATP:protein phosphotransferase; EC 2.7.1.37) has been studied in rat and guinea pig cerebrum. These endogenous substrates, referred to as proteins Ia and Ib, have been shown in other studies to be specific to nervous tissue and to be enriched in the synaptic membrane and synaptic vesicle fractions of adult brain. In the present study, proteins Ia and Ib were shown to increase markedly during the time of major synaptogenesis in rat cerebrum and guinea pig cerebrum, in which the morphological development of synapses is predominantly postnatal and prenatal, respectively. Similar results were obtained either by measuring endogenous phosphorylation of proteins Ia and Ib in the synaptic membrane fraction or by measuring phosphorylation of extracted proteins Ia and Ib with added protein kinase.

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Year: 1978 PMID： 211513 PMCID： PMC392926 DOI： 10.1073/pnas.75.8.4037

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

14 in total

1. Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. II. Solubilization, purification, and some properties of an endogenous adenosine 3':5'-monophosphate-dependent protein kinase.

Authors: I Uno; T Ueda; P Greengard
Journal: J Biol Chem Date: 1977-07-25 Impact factor: 5.157

2. Widespread occurrence of a specific protein in vertebrate tissues and regulation by cyclic AMP of its endogenous phosphorylation and dephosphorylation.

Authors: A M Malkinson; B K Krueger; S A Rudolph; J E Casnellie; B E Haley; P Greengard
Journal: Metabolism Date: 1975-03 Impact factor: 8.694

3. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

4. The relationship between mammalian foetal weight and conception age.

Authors: A S G HUGGETT; W F WIDDAS
Journal: J Physiol Date: 1951-07 Impact factor: 5.182

5. Regulation of endogenous phosphorylation of specific proteins in synaptic membrane fractions from rat brain by adenosine 3':5'-monophosphate.

Authors: T Ueda; H Maeno; P Greengard
Journal: J Biol Chem Date: 1973-12-10 Impact factor: 5.157

6. The formation of synaptic junctions in developing rat brain: a quantitative electron microscopic study.

Authors: G K Aghajanian; F E Bloom
Journal: Brain Res Date: 1967-12 Impact factor: 3.252

7. Synaptogenesis in guinea-pig cerebral cortex: a glutaral-dehyde-PTA study.

Authors: D G Jones; M M Dittmer; L C Reading
Journal: Brain Res Date: 1974-04-19 Impact factor: 3.252

8. Synaptogenesis in the corpus striatum of infant rat.

Authors: T Hattori; P L McGeer
Journal: Exp Neurol Date: 1973-01 Impact factor: 5.330

9. Purification of phosphoprotein phosphatase from bovine cardiac muscle that catalyzes dephosphorylation of cyclic AMP-binding protein component of protein kinase.

Authors: C K Chou; J Alfano; O M Rosen
Journal: J Biol Chem Date: 1977-05-10 Impact factor: 5.157

10. Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.

Authors: T Ueda; P Greengard
Journal: J Biol Chem Date: 1977-07-25 Impact factor: 5.157

23 in total

Review 1. The formation of synapses in the central nervous system.

Authors: Adriana Ferreira; Sabrina Paganoni
Journal: Mol Neurobiol Date: 2002-08 Impact factor: 5.590

2. The ontogeny of the uptake systems for glutamate, GABA, and glycine in synaptic vesicles isolated from rat brain.

Authors: H Christensen; F Fonnum
Journal: Neurochem Res Date: 1992-05 Impact factor: 3.996

3. Thyroid hormone enhances the formation of synapses between cultured neurons of rat cerebral cortex.

Authors: Ritsuko Hosoda; Kenji Nakayama; Midori Kato-Negishi; Masahiro Kawahara; Kazuyo Muramoto; Yoichiro Kuroda
Journal: Cell Mol Neurobiol Date: 2003-12 Impact factor: 5.046

4. Synapsin III: developmental expression, subcellular localization, and role in axon formation.

Authors: A Ferreira; H T Kao; J Feng; M Rapoport; P Greengard
Journal: J Neurosci Date: 2000-05-15 Impact factor: 6.167

Review 5. Neuronal phosphoproteins. Mediators of signal transduction.

Authors: P Greengard
Journal: Mol Neurobiol Date: 1987 Spring-Summer Impact factor: 5.590

6. Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices.

Authors: J Forn; P Greengard
Journal: Proc Natl Acad Sci U S A Date: 1978-10 Impact factor: 11.205

7. Effects of neonatal cerebral hypoxia-ischemia on the in vitro phosphorylation of synapsin 1 in rat synaptosomes.

Authors: M B Moretto; A de Mattos-Dutra; N Arteni; R Meirelles; M S de Freitas; C A Netto; R Pessoa-Pureur
Journal: Neurochem Res Date: 1999-10 Impact factor: 3.996

8. Synapsin IIa accelerates functional development of neuromuscular synapses.

Authors: E Schaeffer; J Alder; P Greengard; M M Poo
Journal: Proc Natl Acad Sci U S A Date: 1994-04-26 Impact factor: 11.205

9. Diffuse alterations in synaptic protein expression following focal traumatic brain injury in the immature rat.

Authors: G T Gobbel; C Bonfield; E B Carson-Walter; P D Adelson
Journal: Childs Nerv Syst Date: 2007-04-25 Impact factor: 1.475

10. Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology.

Authors: Winnie S Liang; Travis Dunckley; Thomas G Beach; Andrew Grover; Diego Mastroeni; Keri Ramsey; Richard J Caselli; Walter A Kukull; Daniel McKeel; John C Morris; Christine M Hulette; Donald Schmechel; Eric M Reiman; Joseph Rogers; Dietrich A Stephan
Journal: Neurobiol Aging Date: 2008-06-24 Impact factor: 4.673