| Literature DB >> 21151209 |
Claudia Seikrit1, Anja Mühlfeld, Hermann-Josef Groene, Jürgen Floege.
Abstract
BACKGROUND: A 47-year-old man with a 6-year history of chronic dialysis for end-stage renal disease of unknown etiology presented for renal transplantation. While on dialysis, he had developed secondary hyperparathyroidism, which persisted after transplantation despite treatment with cinacalcet. INVESTIGATIONS: Physical examination, serum and urine analysis, ultrasound of the renal transplant, renal biopsy, bone scintigraphy. DIAGNOSIS: Severe persistent hyperparathyroidism associated with mild hypercalcemia following renal transplantation. Initiation of a calcimimetic followed by fulminant graft failure. Extensive tubular calcinosis. MANAGEMENT: Renal transplantation (with immunosuppressant medications: basiliximab, tacrolimus, mycophenolate mofetil, prednisolone), cinacalcet (halted on day 26 after transplantation), angiotensinconverting-enzyme inhibitor, angiotensin-receptor blocker, hydrochlorothiazide, emergency dialysis, subtotal parathyroidectomy.Entities:
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Year: 2010 PMID： 21151209 DOI： 10.1038/nrneph.2010.169
Source DB: PubMed Journal: Nat Rev Nephrol ISSN： 1759-5061 Impact factor: 28.314