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Literature DB >> 21151175

Apoptosis promotes early tumorigenesis.

Abstract

One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.

Entities: Disease Gene

Mesh：

Year: 2010 PMID： 21151175 DOI： 10.1038/onc.2010.573

Source DB: PubMed Journal: Oncogene ISSN： 0950-9232 Impact factor: 9.867

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Cited

21 in total

1. p53/HMGB1 complexes regulate autophagy and apoptosis.

Authors: Kristen M Livesey; Rui Kang; Philip Vernon; William Buchser; Patricia Loughran; Simon C Watkins; Lin Zhang; James J Manfredi; Herbert J Zeh; Luyuan Li; Michael T Lotze; Daolin Tang
Journal: Cancer Res Date: 2012-02-16 Impact factor: 12.701

Review 2. DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death.

Authors: Qiuhong Zhang; Rui Kang; Herbert J Zeh; Michael T Lotze; Daolin Tang
Journal: Autophagy Date: 2013-02-06 Impact factor: 16.016

3. The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.

Authors: Rui Kang; Tara Loux; Daolin Tang; Nicole E Schapiro; Philip Vernon; Kristen M Livesey; Alyssa Krasinskas; Michael T Lotze; Herbert J Zeh
Journal: Proc Natl Acad Sci U S A Date: 2012-04-16 Impact factor: 11.205

4. High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases.

Authors: Wei Yan; Ying Chang; Xiaoyan Liang; Jon S Cardinal; Hai Huang; Stephen H Thorne; Satdarshan P S Monga; David A Geller; Michael T Lotze; Allan Tsung
Journal: Hepatology Date: 2012-06 Impact factor: 17.425

5. The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.

Authors: Erin K Daugherity; Gabriel Balmus; Ahmed Al Saei; Elizabeth S Moore; Delbert Abi Abdallah; Arlin B Rogers; Robert S Weiss; Kirk J Maurer
Journal: Cell Cycle Date: 2012-05-15 Impact factor: 4.534

Apoptosis promotes early tumorigenesis.

1. p53/HMGB1 complexes regulate autophagy and apoptosis.

Review 2. DAMPs and autophagy: cellular adaptation to injury and unscheduled cell death.

3. The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia.

4. High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases.

5. The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.

6. Expression of c-Myc and Fas correlates with perineural invasion of pancreatic cancer.

7. Upregulation of Cyclin B2 (CCNB2) in breast cancer contributes to the development of lymphovascular invasion.

8. Migfilin sensitizes cisplatin-induced apoptosis in human glioma cells in vitro.

9. Autophagy in pancreatic cancer pathogenesis and treatment.

10. Lymphatics, lymph nodes and the immune system: barriers and gateways for cancer spread.