Literature DB >> 21150733

Evolution of surgical treatment for sarcomas of proximal humerus in children: retrospective review at a single institute over 30 years.

Marco Manfrini1, Akshay Tiwari, John Ham, Marco Colangeli, Mario Mercuri.   

Abstract

BACKGROUND: Proximal humerus, although a common site for primary bone sarcomas, finds scant mention in literature as far as options and outcome of reconstruction in the skeletally immature skeleton are concerned. Reconstruction after resection of proximal humeral sarcomas in the immature skeleton poses specific challenges to the surgeon, and there has been a definite evolution of these techniques over the decades. We studied the evolution and compared the outcome of various techniques for such reconstruction over 3 decades at a single institution.
METHODS: All 61 children younger than 13 years of age and treated for a primary sarcoma of the proximal humerus at Department of Musculoskeletal Oncology, Rizzoli Orthopedic Institute, from 1976 to 2006 were studied for techniques of resection and reconstruction, complications, surgical procedures needed during follow up, and functional and radiologic outcomes during and at final follow-up. The functional outcomes after various procedures were compared using the Musculoskeletal Tumor Society scoring system.
RESULTS: A definite trend from amputation in the first decade, to the use of nonbiological reconstruction (endoprostheses, K nail cement spacer) in the second and biological reconstruction (vascular proximal fibula autograft, osteoarticular allograft, and allograft prosthesis composite) in the third decade was seen. There was a trend of improvement in the functional outcome over the 3 decades, although the complication rates and the need for repeated surgical procedures remained a major problem in all the techniques.
CONCLUSIONS: Reconstruction of proximal humerus after resection for sarcomas is a challenging task. Although endoprostheses do have a definite role to play in reconstruction of proximal humerus in children, the use of biological techniques in well-selected patients is being carried out more often now than before, as is reflected in this series, with a potentially improved functional outcome. LEVEL OF EVIDENCE: Level III-Retrospective comparative study.

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Year:  2011        PMID: 21150733     DOI: 10.1097/BPO.0b013e318202c223

Source DB:  PubMed          Journal:  J Pediatr Orthop        ISSN: 0271-6798            Impact factor:   2.324


  17 in total

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Authors:  Deepak Gautam; Rajesh Malhotra
Journal:  J Clin Orthop Trauma       Date:  2017-09-25

2.  Effect of marital status on treatment and survival of extremity soft tissue sarcoma.

Authors:  V K Alamanda; Y Song; G E Holt
Journal:  Ann Oncol       Date:  2014-02-06       Impact factor: 32.976

3.  What Are the Complications of Allograft Reconstructions for Sarcoma Resection in Children Younger Than 10 Years at Long-term Followup?

Authors:  Luis A Aponte-Tinao; Jose I Albergo; Miguel A Ayerza; D Luis Muscolo; Federico Milano Ing; German L Farfalli
Journal:  Clin Orthop Relat Res       Date:  2018-03       Impact factor: 4.176

4.  Proximal humeral osteoarticular allografts: technique, pearls and pitfalls, outcomes.

Authors:  German L Farfalli; Miguel A Ayerza; D Luis Muscolo; Luis A Aponte-Tinao
Journal:  Curr Rev Musculoskelet Med       Date:  2015-12

5.  Proximal humerus allograft prosthetic composites: technique, outcomes, and pearls and pitfalls.

Authors:  Santiago A Lozano-Calderón; Neal Chen
Journal:  Curr Rev Musculoskelet Med       Date:  2015-12

Review 6.  Current concepts in surgical treatment of osteosarcoma.

Authors:  Akshay Tiwari
Journal:  J Clin Orthop Trauma       Date:  2012-06-16

7.  Does total humeral endoprosthetic replacement provide reliable reconstruction with preservation of a useful extremity?

Authors:  Hazem Wafa; Krishna Reddy; Robert Grimer; Adesegun Abudu; Lee Jeys; Simon Carter; Roger Tillman
Journal:  Clin Orthop Relat Res       Date:  2015-03       Impact factor: 4.176

Review 8.  Outcome after reconstruction of the proximal humerus for tumor resection: a systematic review.

Authors:  Teun Teunis; Sjoerd P F T Nota; Francis J Hornicek; Joseph H Schwab; Santiago A Lozano-Calderón
Journal:  Clin Orthop Relat Res       Date:  2014-01-28       Impact factor: 4.176

9.  Is claviculo pro humeri of value for limb salvage of pediatric proximal humerus sarcomas?

Authors:  George T Calvert; Jennifer Wright; Jayant Agarwal; Kevin B Jones; R Lor Randall
Journal:  Clin Orthop Relat Res       Date:  2015-03       Impact factor: 4.176

Review 10.  Fractures in bone tumour prosthesis.

Authors:  Andrea Piccioli; Barbara Rossi; Federico Maria Sacchetti; Maria Silvia Spinelli; Alberto Di Martino
Journal:  Int Orthop       Date:  2015-08-26       Impact factor: 3.075

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