Søren E Degn1, Jens C Jensenius, Mette Bjerre. 1. Department of Medical Microbiology and Immunology, Aarhus University, and Medical Research Laboratories, Clinical Institute & Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Abstract
PURPOSE OF REVIEW: To give a comprehensive overview of the recently published studies on the role of the lectin pathway in coagulation, infections and auto-immunity. RECENT FINDINGS: We present the status quo picture of the lectin pathway, including the newly discovered member, MAp44 (a.k.a. MAP-1), which may act as a specific regulator of activation. On the functional side the focus is on the important discoveries of the connections between the coagulation system and mannose-binding lectin-associated serine proteases, newly discovered associations between the lectin pathway and infectious diseases, especially among neonates, the recent findings of the involvement of mannan-binding lectin and ficolins in auto-immune disorders, and novel therapeutic avenues. The involvement of the lectin pathway in ischemia-reperfusion injuries and transplantations is discussed elsewhere in this issue. SUMMARY: The emerging picture of the lectin pathway is that it may play a role in the case of concomitant impairments of cellular and adaptive immunity, as seen in the case of premature infants, neonates, neutropenic cancer patients and the like. Considering the near-exponential increase in interest for the lectin pathway and its intricacies in recent years, the future of the field seems promising.
PURPOSE OF REVIEW: To give a comprehensive overview of the recently published studies on the role of the lectin pathway in coagulation, infections and auto-immunity. RECENT FINDINGS: We present the status quo picture of the lectin pathway, including the newly discovered member, MAp44 (a.k.a. MAP-1), which may act as a specific regulator of activation. On the functional side the focus is on the important discoveries of the connections between the coagulation system and mannose-binding lectin-associated serine proteases, newly discovered associations between the lectin pathway and infectious diseases, especially among neonates, the recent findings of the involvement of mannan-binding lectin and ficolins in auto-immune disorders, and novel therapeutic avenues. The involvement of the lectin pathway in ischemia-reperfusion injuries and transplantations is discussed elsewhere in this issue. SUMMARY: The emerging picture of the lectin pathway is that it may play a role in the case of concomitant impairments of cellular and adaptive immunity, as seen in the case of premature infants, neonates, neutropenic cancerpatients and the like. Considering the near-exponential increase in interest for the lectin pathway and its intricacies in recent years, the future of the field seems promising.
Authors: R M Kjærup; T S Dalgaard; L R Norup; R M Goto; M M Miller; P Sørensen; H R Juul-Madsen Journal: Immunogenetics Date: 2014-09-04 Impact factor: 2.846
Authors: Christian Gytz Ammitzbøll; Rudi Steffensen; Hans Jørgen Nielsen; Steffen Thiel; Kristian Stengaard-Pedersen; Martin Bøgsted; Jens Christian Jensenius Journal: PLoS One Date: 2013-09-02 Impact factor: 3.240
Authors: Christian Gytz Ammitzbøll; Troels Rønn Kjær; Rudi Steffensen; Kristian Stengaard-Pedersen; Hans Jørgen Nielsen; Steffen Thiel; Martin Bøgsted; Jens Christian Jensenius Journal: PLoS One Date: 2012-11-28 Impact factor: 3.240