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Literature DB >> 211506

Post-transcriptional suppression of globin gene expression in cells transformed by avian erythroblastosis virus.

Abstract

Cells transformed by avian erythroblastosis virus were grown in vitro for up to 5 months. After a few days in culture, synthesis of hemoglobin was undetectable and could not be induced by dimethyl sulfoxide. As shown by globin cDNA hybridization to nuclear and cytoplasmic RNA carried to Crot values of 10(5) moles of nucleotide per liter X sec, globin genes in these cells are transcribed into pre-mRNA, but no trace of globin mRNA appears in the cytoplasm. The implications of this observation for schemes of post-transcriptional regulations and viral transformation are discussed.

Entities: Chemical Gene Species

Mesh：

Substances：
RNA, Messenger
Globins

Year: 1978 PMID： 211506 PMCID： PMC392869 DOI： 10.1073/pnas.75.8.3776

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

32 in total

1. REGULATION OF THE INITIATION OF CHICK EMBRYO HEMOGLOBIN SYNTHESIS.

Authors: F H WILT
Journal: J Mol Biol Date: 1965-06 Impact factor: 5.469

2. Evidence for a translational inhibitor linked to globin mRNA in untranslated free cytoplasmic messenger ribonucleoprotein complexes.

Authors: O Civelli; A Vincent; J F Buri; K Scherrer
Journal: FEBS Lett Date: 1976-12-15 Impact factor: 4.124

3. A precursor of globin messenger RNA.

Authors: J Ross
Journal: J Mol Biol Date: 1976-09-15 Impact factor: 5.469

4. Globin RNA precursor molecules: biosynthesis and process in erythroid cells.

Authors: R N Bastos; H Aviv
Journal: Cell Date: 1977-07 Impact factor: 41.582

5. In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA.

Authors: I M Verma; G F Temple; H Fan; D Baltimore
Journal: Nat New Biol Date: 1972-02-09

6. Messenger RNA in eukaryotic cells: the life history of duck globin messenger RNA.

Authors: K Scherrer
Journal: Acta Endocrinol Suppl (Copenh) Date: 1973

7. Synthesis of mouse haemoglobin and globin mRNA in leukaemic cell cultures.

Authors: W Ostertag; H Melderis; G Steinheider; N Kluge; S Dube
Journal: Nat New Biol Date: 1972-10-25

8. Comparison of the base-sequence complexities of polysomal and nuclear RNAs in growing Friend erythroleukemia cells.

Authors: L Kleiman; G D Birnie; B D Young; J Paul
Journal: Biochemistry Date: 1977-03-22 Impact factor: 3.162

9. Purification of globin messenger RNA from dimethylsulfoxide-induced Friend cells and detection of a putative globin messenger RNA precursor.

Authors: P J Curtis; C Weissmann
Journal: J Mol Biol Date: 1976-10-05 Impact factor: 5.469

10. Purification of a putative precursor of globin messenger RNA from mouse nucleated erythroid cells.

Authors: S P Kwan; T G Wood; J B Lingrel
Journal: Proc Natl Acad Sci U S A Date: 1977-01 Impact factor: 11.205

15 in total

1. Genetic test for involvement of intervening sequences in transport of nuclear RNA.

Authors: L P Villarreal; S Carr
Journal: Mol Cell Biol Date: 1982-12 Impact factor: 4.272

2. Transcription of the alpha globin gene domain in normal and AEV-transformed chicken erythroblasts: mapping of giant globin-specific RNA including embryonic and adult genes.

Authors: F Broders; K Scherrer
Journal: Mol Gen Genet Date: 1987-09

3. Expression of a human cytomegalovirus late gene is posttranscriptionally regulated by a 3'-end-processing event occurring exclusively late after infection.

Authors: W F Goins; M F Stinski
Journal: Mol Cell Biol Date: 1986-12 Impact factor: 4.272

4. AEV-transformed erythroleukemia cell induced differentiation: expression of specific cell membrane antigenic molecules.

Authors: I Raynaud; J M Biquard; P Chambard; B Fasciotto; J Samarut; J P Blanchet; V Krsmanovic
Journal: Arch Virol Date: 1987 Impact factor: 2.574

9. Relationship between the transport from isolated nuclei of two abundant cytoplasmic messengers and the source of a messenger RNA transport factor.

Authors: R B Moffett; T E Webb
Journal: Mol Biol Rep Date: 1984-01 Impact factor: 2.316

10. Variation of expression of histocompatibility antigens on tumor cells: absence of H-2Kk-gene products from a gross-virus-induced leukemia in BALB.K.

Authors: W Schmidt; L Leben; G Atfield; H Festenstein
Journal: Immunogenetics Date: 1981 Impact factor: 2.846